A0AAF0B6T5 · A0AAF0B6T5_9CAUD
- ProteinRNA ligase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Involved in countering a host defense mechanism which, following viral infection, activates the host anticodon nuclease and shuts off viral translation. Repairs 5'-PO4 and 3'-OH groups in the cleaved host tRNA.
Catalytic activity
Cofactor
Note: Binds 2 magnesium ions that perform the catalytic activity via a two-metal mechanism. One of the catalytic Mg2+, which is coordinated by 5 water molecules, engages the lysine nucleophile and the ATP alpha phosphate while the Mg2+ orients the PPi leaving group.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 37 | ATP (UniProtKB | ChEBI) | |||
Binding site | 54 | ATP (UniProtKB | ChEBI) | |||
Binding site | 75 | ATP (UniProtKB | ChEBI) | |||
Active site | 99 | N6-AMP-lysine intermediate | |||
Binding site | 159 | ATP (UniProtKB | ChEBI) | |||
Site | 159 | Essential for RNA ligase activity | |||
Binding site | 240 | ATP (UniProtKB | ChEBI) | |||
Binding site | 242 | ATP (UniProtKB | ChEBI) | |||
Site | 246 | Essential for RNA ligase activity | |||
Binding site | 272 | Mg2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | RNA ligase (ATP) activity | |
Biological Process | RNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA ligase 1
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Tequatrovirus
Accessions
- Primary accessionA0AAF0B6T5
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)43,477
- Last updated2024-05-29 v1
- Checksum433CAAC7A271EA80
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
OQ174502 EMBL· GenBank· DDBJ | WCA45997.1 EMBL· GenBank· DDBJ | Genomic DNA |