A0AAE9KHR4 · A0AAE9KHR4_9NEIS

  • Protein
    Purine nucleoside phosphorylase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Purine nucleoside phosphorylase involved in purine salvage.

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; purine nucleoside salvage.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site8phosphate (UniProtKB | ChEBI)
Binding site50-51phosphate (UniProtKB | ChEBI)
Binding site183substrate
Binding site184phosphate (UniProtKB | ChEBI)
Site215Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Purine nucleoside phosphorylase
  • EC number
  • Short names
    PNP

Gene names

    • ORF names
      LVJ78_06850

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1258/02
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Uruburuella

Accessions

  • Primary accession
    A0AAE9KHR4

Proteomes

Subcellular Location

Interaction

Subunit

Homohexamer. Dimer of a homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-237Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    240
  • Mass (Da)
    26,372
  • Last updated
    2024-05-29 v1
  • Checksum
    263AB329C13BE566
MIAIIGGSGLTRLPEMNITHRRIVRTPYGLPSSPLMMGKLGSHEIMFIARHGLNHTLSPHEINYRANIWALHSAKADHIISVATVAGLNEAHEPGSLIVPDNIIDYTSGRACTFFEGRSQEVVHIDFTHPYDHELRLNILQHAEQQGTAVVSRGVYGCIQGPRLPTLAELKKYRRDGVDVIGMTGMPEAVLAREVGLPYAHLCGVIGIAGVNGQADNSPDFRSRQTHQAIETIRRLLVDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP091507
EMBL· GenBank· DDBJ
UOO78438.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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