A0AAE9KHR4 · A0AAE9KHR4_9NEIS
- ProteinPurine nucleoside phosphorylase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids240 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Purine nucleoside phosphorylase involved in purine salvage.
Miscellaneous
Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
Catalytic activity
- a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate
Pathway
Purine metabolism; purine nucleoside salvage.
Features
Showing features for binding site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePurine nucleoside phosphorylase
- EC number
- Short namesPNP
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Uruburuella
Accessions
- Primary accessionA0AAE9KHR4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homohexamer. Dimer of a homotrimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-237 | Nucleoside phosphorylase | ||||
Sequence: IAIIGGSGLTRLPEMNITHRRIVRTPYGLPSSPLMMGKLGSHEIMFIARHGLNHTLSPHEINYRANIWALHSAKADHIISVATVAGLNEAHEPGSLIVPDNIIDYTSGRACTFFEGRSQEVVHIDFTHPYDHELRLNILQHAEQQGTAVVSRGVYGCIQGPRLPTLAELKKYRRDGVDVIGMTGMPEAVLAREVGLPYAHLCGVIGIAGVNGQADNSPDFRSRQTHQAIETIRRLL |
Sequence similarities
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length240
- Mass (Da)26,372
- Last updated2024-05-29 v1
- Checksum263AB329C13BE566
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP091507 EMBL· GenBank· DDBJ | UOO78438.1 EMBL· GenBank· DDBJ | Genomic DNA |