A0AAE9GRI8 · A0AAE9GRI8_9NEIS
- Protein3-dehydroquinate dehydratase
- GenearoD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids252 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Catalytic activity
- 3-dehydroquinate = 3-dehydroshikimate + H2O
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 46-48 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: EFR | ||||||
Binding site | 82 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 143 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Active site | 170 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 213 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 232 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 236 | 3-dehydroquinate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydroquinate dehydratase activity | |
Biological Process | 3,4-dihydroxybenzoate biosynthetic process | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate dehydratase
- EC number
- Short names3-dehydroquinase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Uruburuella
Accessions
- Primary accessionA0AAE9GRI8
Proteomes
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length252
- Mass (Da)26,428
- Last updated2024-05-29 v1
- Checksum4B466CCEE1C7D623
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP091507 EMBL· GenBank· DDBJ | UOO78695.1 EMBL· GenBank· DDBJ | Genomic DNA |