A0AAE9GRI8 · A0AAE9GRI8_9NEIS

  • Protein
    3-dehydroquinate dehydratase
  • Gene
    aroD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site46-483-dehydroquinate (UniProtKB | ChEBI)
Binding site823-dehydroquinate (UniProtKB | ChEBI)
Active site143Proton donor/acceptor
Active site170Schiff-base intermediate with substrate
Binding site2133-dehydroquinate (UniProtKB | ChEBI)
Binding site2323-dehydroquinate (UniProtKB | ChEBI)
Binding site2363-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • ORF names
      LVJ78_08255

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1258/02
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Uruburuella

Accessions

  • Primary accession
    A0AAE9GRI8

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    26,428
  • Last updated
    2024-05-29 v1
  • Checksum
    4B466CCEE1C7D623
MNSIRVKNLIIGSGRPKICVPLVADTPAALQAAVAGLLGVEYDLVEFRADFLNAAADQAQVLACLKSVRAQLPDVPLLFTFRTFAEGGACEMAPADYFDLLHAAAASGDADLIDIELFAGDEGVQAAIAAAKAHGVAVVLCNHDFQQTPAEAEIVGRLCRMQDWGADICKIAVMPQSAADVLTLLSATETMQRCHARRPLITMAMGRLGMVSRLAGEVFGSAVSFGAAGQASAPGQIDAGDLRFILQMLAQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP091507
EMBL· GenBank· DDBJ
UOO78695.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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