A0AAE7S212 · A0AAE7S212_9CAUD

Function

function

Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is due to local fusion between the inner and outer membrane performed by the spanin complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell plasma membrane
Biological Processviral release from host cell by cytolysis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Spanin, inner membrane subunit
  • Short names
    i-spanin
  • Alternative names
    • Lysis protein Rz

Organism names

Accessions

  • Primary accession
    A0AAE7S212

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond99Interchain
Disulfide bond154Interchain

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Interacts (via C-terminus) with the spanin outer lipoprotein subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of one homodimer of the i-spanin linked by intermolecular disulfide bonds involving two Cys residues and one homodimer of the o-spanin covalently linked by an intermolecular disulfide bond involving one Cys.

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil38-86

Domain

The coiled coil region is probably involved in host membrane fusion leading to lysis.

Sequence similarities

Belongs to the Lambdavirus i-spanin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    156
  • Mass (Da)
    17,221
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    1AC6E293D1DF3B41254B38688C0C29BA
MMFNWKTMFVGLLLVSLIVSGRLANHYRDNAISYKEQRDNKASELEKANATITDMQQRQLDADALDAKYTKELADEKAENDALRRKLDNGGRVLVKGKCPVPSSAETSSASGMGNDATVELSPVAGRNVLGIRDGIISDQTALRTLQEYIRTQCLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MW790496
EMBL· GenBank· DDBJ
QXH32916.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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