A0AAE6TXE0 · A0AAE6TXE0_9NIDO

  • Protein
    Replicase polyprotein 1ab
  • Gene
    ORF1B
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site1388
Active site1390
Active site1489
Active site1565
Active site1570
Active site1870
Active site1887
Active site1921

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functionendonuclease activity
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Replicase polyprotein 1ab
  • Alternative names
    • ORF1ab polyprotein

Gene names

    • Name
      ORF1B

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L25
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Tornidovirineae > Tobaniviridae > Serpentovirinae

Accessions

  • Primary accession
    A0AAE6TXE0

Proteomes

Subcellular Location

Host membrane
; Multi-pass membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-207NiRAN
Domain505-657RdRp catalytic
Domain812-893CV ZBD
Domain1037-1372+RNA virus helicase C-terminal
Domain1370-1590ExoN
Domain1831-1976NendoU

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,251
  • Mass (Da)
    255,425
  • Last updated
    2024-05-29 v1
  • Checksum
    3938FE7C447207A0
MPPLESELTTHYVNVNSTTSGIYALTKMHTTSVNIGNQNYTIKACTQEQVEHEMKYYKALSKTLPIVHHQVIDTPYNKMLLRGPMTKKSIGDYVYAYYMAETPIAIDKSKPETLYQQQNIITKVFTDTTFNNLDIIYKNQHLLSGVVTLDNIDTDGMLYDFGDFGLKVEPRLDIAYADLLNYYSQYMLPPHKNFNNWFPINYNAITDGDWLDKVLALNNNILNAPCKTTELFIDVETSTTHAYYNPLFGYKNVNIELIEQQNDLLQQLYYIQDPGMRAIEPIEAISNTITCHKYGEDHDGDAKPVFYNIESYEDLKNRGVDCDSCLNYGYFQGSSSNVKADFNFYTYQSNLFLPPHLLKFLYTQTLKDFSVNATDKRYSYEDCKPNKSSLGPSHPILRGVKQDKVYDTLPDDVIEKLVQLAIATPLIFTTKVTDKFALTAKARARTIAACSMFASTLFRACHKPVTANFVTKAQNCESHCLIGVSKFYQHFDRFIRNRYGNLSDYNVFGSDYTKCDRSFPLIFRAMAAALLFELGEWDPKGHLFVNEIQAFMLDFVMVGESIFQKPGGTSSGDATTAFANTLYNHMVHLYVQLQHLVTSPVHSNHTHLKNAAVKLWQTGDFELYSMFLDQYNSRDYRFNFLSDDSFILTRKEDPTLPNIFNTYNFSRRLETLIHTVVDDSKAWQGEDIHEFCSSHIVEVDGVYQFVPDKNRLVAALLITGKAPDEELDVIRTAAILAEAAIYSSVDSPFWKALYNHYLSKYDAYTLKYDCVPLPNAMRDEAFFKVMISAKGESYYQLFETAMSGFELQATEAVTTCYCCPNITVSRCLSCPVAYPLCASCAYTHYCDTKHLVTHLPKCKEYGCGENDPAQLYYCSEKNVVDVYCKDHVRGFYLPTIDHMRALLRIPHSNSCVKQHDDVKALSDTLDEATRIQYFSYNPHQSVNFNQLRLVHHSYIAAAYSEAHEPTCTYDVVDFDGRVIKIMDSKGNDPCYGFTTYCNIYDAKDHVVVKCTADPLGNSLYHLTFVDFTTKFARCNKIVRTPHQTKLLPLTAFKALTNAQFILGPPGTGKTTYFINTYFSNSSAFNRVIYCAPTHKLIQDMDRALGQRNDVSVIVSKHNNREYLNTLNNTEASILLGTINVLRPVKGSTLLVDECSLLTPVQLLEAINQVCPSRIVIVGDPFQLAPVLPSREFNWSYTGFYLNHLIHKANVTSLSCCYRCPSEIFNSFAKPYRDAGITFYPNKDGGEFKLNITKFHYNQNLIDEKLIDELASKFDVVLSNYKAATVYATNKNHHNVITIDSAQGLTAAKVAVVVFGHSNFSKVINRLIVAFSRATTKLEIFVDQPLGDYIKSHLMLNPQIDLQSASLHEDHIVSVDYVANNISATGVCDIEFYHCKQPGLSNHLGLGEITVYTTKVHSCFIRPRYIKHGLNKELNNHEIFTSGQWKYMMYRLPTKEQSVVFTNNLIEHILNTTDLTNSPFIFLLYNGSHDIDALQQICTYGEYKCDDCNSPARAMTDHGVFCADHATRQSKPLTHLINPKFYSYNAPTKLVVEHATVCKYDHGVAHSSSVDVNMTACIIGNQLAQCTPLYTNNYGWVKVSYSSFDIDNRYYGQHLFYKNQLIKYPHTPIKTLPPPPGKHDSIYCIKPPTIPHGCHPTSPIHICSQCLWYYKQFYTAQYHYADYGFEYQNNVVLQALTTKQKQLKLSAELIPMSNGDLMVSCGGIVVPFFQNLDQTIKKVSFYGNYPIPKQSVLSGLCVTCSYKIAVPSVPVKDLDEIKPWDIVISYEELAIPNKQVILSMHPPSKKYKWHGSATAALCLPTSTTPFVNKSGTPSFYLRTVNFEVPDTLWSTGRIENKDFYKFPHEGIFNVHIDLGEASNESYTIGGNHMFPSAFEHTNFSETYSDVNKPTHNLSIVKFKGVKSCCSVIDVFTNDFYELLHTMINEKTISLKTTIYIDFQPIPIMIWASDGVISTAYTQAGGRDVRSNVDQLFQSNDHYVEWRPIPCAIPQEIDRPQGFHVAKTKLHQTNNVTKYIQICNYINDNVKLAPRPKILDFGASSGESHDYLPVGGIILEHFFGDLCDHFDIQQITSRPNFKEGKYDLIVSDVFVEGDEAVDNTSLLIETIENHLSPGGTILWKTTRRNQIKTLQTISLNFGSVTYFTPRCNLDSSEVYICLAYYGGSMTEDACLFDYDVLQAIAIIRANYSLMVKDSAMDLSFKHKPAPVTTVPKYMMPRVTTKMWKTGRFRCIAG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN161572
EMBL· GenBank· DDBJ
QFU19812.1
EMBL· GenBank· DDBJ
Genomic RNA

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