A0AAE5QYM9 · A0AAE5QYM9_STAEP

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site32NADPH (UniProtKB | ChEBI)
Binding site49NADPH (UniProtKB | ChEBI)
Binding site106NADPH (UniProtKB | ChEBI)
Binding site106sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site106substrate
Binding site137sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site139sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site141NAD+ (UniProtKB | ChEBI)
Binding site141NADPH (UniProtKB | ChEBI)
Active site192Proton acceptor
Binding site192sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site245sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site256NAD+ (UniProtKB | ChEBI)
Binding site256NADPH (UniProtKB | ChEBI)
Binding site256sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site256-257substrate
Binding site257sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site280NADPH (UniProtKB | ChEBI)
Binding site282NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      CTJ08_00735

Organism names

  • Taxonomic identifier
  • Strain
    • SCH-17
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0AAE5QYM9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-160Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain181-321Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    36,133
  • Last updated
    2024-05-29 v1
  • Checksum
    8FC0AB44FC40C282
MRKITIFGMGSFGTALANVLAQNGHDVLMWGKNVENVDELNTHHMNKNYLKDAKLDSSIKATVDLNKAVQFSDIYLMALPTKAIREVSKDIDQLLTSKKTFIHVAKGIENDTFKRVSEMIEDSISSEHNGGIGVLSGPSHAEEVVIKQPTTVAASSKDNNVSKLIQDLFMNDYLRVYTNNDLVGVELGGALKNIIAIASGIVAGMGYGDNAKAALMTRGLAEISRLGEKLGADPMTFLGLGGIGDLIVTCTSTHSRNYTLGFKLGQGKTAEEALKEMKMVVEGIYTTKSVYHLAQQEGVEMPITNALYEVLFEDVPVSKSVRTLMERDKKAE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PEJG01000001
EMBL· GenBank· DDBJ
PIH11397.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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