A0AAE4ZH89 · A0AAE4ZH89_RHOHA

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site28-33GTP (UniProtKB | ChEBI)
Binding site149-152GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      A5N68_05875
      , GS453_26090
      , GS505_10050

Organism names

Accessions

  • Primary accession
    A0AAE4ZH89

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-202Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    622
  • Mass (Da)
    68,833
  • Last updated
    2024-05-29 v1
  • Checksum
    AC2C25F3A637107C
MGLSSNFAEKTFTDPSKIRNFCIIAHIDHGKSTLADRMLQLTGVVEERAMRAQYLDRMDIERERGITIKAQNVRLPWTVQNEDGTTEEIVLHLIDTPGHVDFTYEVSRALEACEGAILLVDAAQGIEAQTLANLYLAMEKDLTIIPVLNKIDLPAADPERYAAEIAHIVGCEAEDVLKVSGKTGVGVKELLDEVVKQVPAPVGDADGPARAMIFDSVYDAYRGVVTYVRVVDGKIRPREKITMMSTGTTHELLEVGIISPEPKATTGLGVGEVGYLITGVKDVRQSRVGDTVTTFRNGASEPLTGYRDPKPMVYSGLYPMDGSDYPVLRDALDKLRLNDAALAYEPETSVALGFGFRCGFLGLLHMEITRDRLEREFGLDLISTAPNVVYRVVMEDGSEHEVTNPSYWPEGKVREVYEPMAKCTVIAPSEYTGAIMELCQSRRGELGGMDYLSETRVELRYTLPMGEIMFDFFDALKSRTKGYASLDYEESGEQQAALVKVDILLQGETVDAFSAIVHKDAAFAYGNKMTTKLRELIPRQQFEVPIQAAIGSKIIARENIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSNESVADKPKGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WUXD01000097
EMBL· GenBank· DDBJ
MBM4630052.1
EMBL· GenBank· DDBJ
Genomic DNA
WUYZ01000001
EMBL· GenBank· DDBJ
NKS26163.1
EMBL· GenBank· DDBJ
Genomic DNA
LWIC01000002
EMBL· GenBank· DDBJ
ORM29428.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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