A0AAE4ZFE5 · A0AAE4ZFE5_RHOHA

Function

function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17ATP (UniProtKB | ChEBI)
Binding site16Mg2+ (UniProtKB | ChEBI)
Active site37
Binding site41substrate
Binding site50ATP (UniProtKB | ChEBI)
Binding site50Mg2+ (UniProtKB | ChEBI)
Binding site109Mg2+ (UniProtKB | ChEBI)
Binding site109-112ATP (UniProtKB | ChEBI)
Binding site170-171ATP (UniProtKB | ChEBI)
Binding site201ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondethiobiotin synthase activity
Molecular Functionmagnesium ion binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent dethiobiotin synthetase BioD
  • EC number
  • Alternative names
    • DTB synthetase
      (DTBS
      )
    • Dethiobiotin synthase

Gene names

    • Name
      bioD
    • ORF names
      GS505_08125

Organism names

Accessions

  • Primary accession
    A0AAE4ZFE5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    23,334
  • Last updated
    2024-05-29 v1
  • Checksum
    0BCA23AA4B36C781
MSVLVISGTSTDVGKTVVTAALAAALRAAGQSVAVCKPAQTGVTVDEPGDLAEVTRLSAVTATVELARYPEPLAPDTAARRAALPMLTQPEVVAATRDLDARHDVTLVEGAGGLLVRLGADGFTVRDVAAELGAPVVVVAAAGLGTLNHCALTAEALAAAGVKCSGFVVGSWPRRPDLAARCNLHDLPAVTGSAVVGRVPEGVAGSDAAGFAATAPTWFEPDWLDSLLIRR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WUYZ01000001
EMBL· GenBank· DDBJ
NKS25800.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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