A0AAE4ZDG9 · A0AAE4ZDG9_RHOHA

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site283pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site325-328pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site328substrate
Binding site369substrate
Binding site373substrate
Active site400Proton donor
Binding site401substrate
Binding site430pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site430substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      GS505_02155

Organism names

Accessions

  • Primary accession
    A0AAE4ZDG9

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue97N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-29Disordered
Domain73-331Orn/DAP/Arg decarboxylase 2 N-terminal
Domain337-428Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    50,302
  • Last updated
    2024-05-29 v1
  • Checksum
    93977D268BD2219A
MNAHPAGPRHAEIQHAPGLPPRPATASEMTALPEQVWPRSAERGADGVVRIAGVPVTELAEKYGTPLFVVDEDDFRSRCREMARAFGGAERVHYASKAFLSAEIARWVRDEGLSMDVASGGELAVALHAGFPAERITMHGNNKSVAELDAAVAAGVGHIVLDSMVEIERLDEVAARRGVVQDVLIRITVGVEAHTHEFIATAHEDQKFGFSLSGGKAIAAVARVFETGNLRLVGLHSHIGSQIFEVDGFELAAHRVIGLMREIVDRFGAEKTSQLSMVDLGGGLGISYLPSDNPPPVAELAAKLAHIVATESAAAGLPVPTLMVEPGRAIAGPGTVTLYEVGTIKDVTLDAGATRRYVSVDGGMSDNIRTSLYQAEYDARLVSRDSDGAPVVARVVGKHCESGDIVIRDAWMPDDLGPGDLLAVAATGAYCYSMSSRYNLLTRPAVVAVRDGASRLILRRETVEDLLSLEVSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WUYZ01000001
EMBL· GenBank· DDBJ
NKS24680.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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