A0AAE4Q5N7 · A0AAE4Q5N7_STRCB
- ProteinGlutamine--fructose-6-phosphate aminotransferase [isomerizing]
- GeneglmS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids604 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Catalytic activity
- D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 2 | Nucleophile; for GATase activity | ||||
Sequence: C | ||||||
Active site | 599 | For Fru-6P isomerization activity | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | glutamine-fructose-6-phosphate transaminase (isomerizing) activity | |
Biological Process | carbohydrate derivative biosynthetic process | |
Biological Process | carbohydrate metabolic process | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutamine--fructose-6-phosphate aminotransferase [isomerizing]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA0AAE4Q5N7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-218 | Glutamine amidotransferase type-2 | ||||
Sequence: CGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANDNQSNLIKSVGRITDLRAKIGIDVAGSTGIGHTRWATHGQSTEGNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKALNIIEGSYAFALMDSQATDTIYVAKNKSPLLIGLGEGYNMICSDAMAMIRETSEFMEIHDKEVVVLTKD | ||||||
Domain | 284-423 | SIS | ||||
Sequence: IISSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEANGK | ||||||
Domain | 456-594 | SIS | ||||
Sequence: VQALLSTTRSAFYIGRGNDYYVAMEAALKLKEISYIQCEGFAAGELKHGTISLIEEGTPVIGLISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLEREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKP |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)65,514
- Last updated2024-05-29 v1
- Checksum916D22C459B32691