A0AAE1LQH4 · A0AAE1LQH4_9NEOP

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site282Nucleophile
Active site366
Active site368

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • CAD protein

Gene names

    • ORF names
      KUF71_016555

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PL_HMW_Pooled
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Thysanoptera > Terebrantia > Thripoidea > Thripidae > Frankliniella

Accessions

  • Primary accession
    A0AAE1LQH4

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain553-745ATP-grasp
Domain1087-1278ATP-grasp
Domain1343-1561MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,323
  • Mass (Da)
    256,574
  • Last updated
    2024-05-29 v1
  • Checksum
    C08895CBD2AFBEAB
MWKLERTRADRLADKMCLTVAEQQPCALVLEDGTVLQGRSFGAPVATHGEVVFQTGMVGYPESLTDPSYHAQILVLTYPLVGNYGVPNEELDEHGLPRYFESRRIWAAGLVVGEICDTPSHWAMARTLSQWLGTHGIPGICGIDTRALTQRLRERGSILGHIVMGPNPAPSQSLSFLDPNTRNLVAEVSIKAPITYNPSGSPRICAVDCGLKYNQLRCLLKRGVRVDMVPWNHPLDPSQFDGLFLSNGPGDPAMCSVTVENIKKLLAAKPGTPQLKPIFGICLGHQLLSTAAGCRTYKMIYGNRGHNQPVTHHGTERCFMTSQNHGFAVDAKNLPSGWNALFTNTNDKSNEGIVHDSMPFFSVQFHPEHTPGPEDLECLFDVFLDEVKAHAQSWGRGSGVKMADRIHDRLVYRPAPGVIPPCPEKPPRKVLILGSGGLSIGQAGEFDYSGSQALKALREQNIHTVLINPNIATVQTSKGLADKVYFLPLIPEYVEQVICHERPDGVLLTFGGQTALNCGVSLNEAGVFEKYNVKILGTPIQAIIDTEDRKVFAERVNEIGEKVAPSCAVNSVQEALDAAEKLGYPVLARAAFSLGGLGSGFANTAEELRVLATQALAHSSQLIVDKSLKGWKEVEYEVVRDAYDNCITVCNMENVDPLGIHTGESIVVAPSQTLSNLEYNKLRSTALKVIRHLGIVGECNIQYAVSPTSNEFYIIEVNARLSRSSALASKATGYPLAYVAAKLSLGLRLPDIRNSVTGSTTACFEPSLDYCVVKIPRWDLAKFARVCSKIGSSMKSVGEVMSIGRCFEEAFQKALRMVDENIKGFDPSIRPVDDAELEAPTDKRTFVLAAAFSAGYTIDRLYELTKIDRWFLHKMRNIIEFQSILESLNQGTLSRDLLLQAKQLGFCDTQIATFVKSTELAVRKFREEVKVLPFVKQIDTVAAEWPAMTNYLYLTYNGSAHDIAFNRGSTMVIGSGVYRIGSSVEFDWCAVGCLRELRRLGRKTIMVNYNPETVSTDYDMVDRLYFEEISFEVVMDIYNAENPEGIILSMGGQLPNNIAMDLHRQQARIFGTSPDSVDSAENRFKFSRMLDRNGIGQPRWKELTNLESAKSFCNEVGYPCLVRPSYVLSGAAMNVAHTPQDLETYLNTASNVSKEHPVVISKFILEAKEIDVDAVACDGAILCMAVSEHVENAGVHSGDATLITPPQDINEQTLCRITAIAKAIAGHLEVTGPFNMQLIAKDNDIKVIECNVRVSRSFPFVSKTLDHDFVAMATRVIVGEKVEPVNVMAGCGKVGCKVPQFSFSRLAGADVMLGVEMASTGEVACFGENRYEAYLKAMMSTGFTIPKHSILLSVGSFKHKMELLPSMQALSKMGYKLYASMGTADFYTEHGVDFFDPSPIAWSESKRQFFSRHRAAAVTHLHVDRRALAVPHEEGPDEGLVDAGHGAQHGHEAEVEPVQWTFENLEATDKEEKGELKHLADFLAKKQFELVINLPMRNGGARRVSSFVTHGYRTRRLAVDYSVPLVTDVKCAKLLVEAMLRIGGAPPMKTHTDCASSSTMVRLPGLIDVHVHVREPGATHKEDYSTCTSAALAGGVTIICAMPNTKPTITDPSAFQLVKELAAAKARCDYAVFVGASSENYSTIRELAPLAAGLKMYLNETFSTLRLKDLTVWRKHMDAWPHNSPLCVHAEGQTTAAVLLLATFQNRPIHVCHVARKEEIQIIRAAKEKGLPVTCEVCPHHLFLTEKDVKHLGEKKSRVKPNLVTEEDQQALWENLDIIDCFATDHAPHTVEEKDSENAPPGFPGLETMLPLLLTAVHEGRLTLEDIKDKLYRNPRRIFNLPEQPNTYVEVNMDAEWTIPDTLQFSKARWTPFAGRKVRGCVQRVVLRGEVAYVDGQVLVPPGFGQDVRELQSRRQPLLNAFSSPSPAVNNCADPTFNGSRPSSAMEFDRPHVLREVDETHRYENGLDGSHERLHHLTPDPQSINRSSSPLLSHTHTRIRYNSESNLYPGAGGQPNSLIGAHVLSVKMFTKDHLNEIFNLAQTMRAFVLKERNLDHILKGKIMASIFYEVSTRTSCSFSAAMLRLGGQVIHMDETSSSVKKGETLEDSVAVMAGYSDVVVLRHPEPGAVNKASAHCRKPLINAGDGIGEHPTQALLDIFTIREEIGTVNGLTITMVGDLRHGRTVHSLARLLTLYNIQLRYVAPPGLGMPQHVVDFVNSKGIPQENYSSLDNALPETDVLYVTRIQKERFASQEEYEKVKGSYVVTPKLMTRAKRKMIVMHPLPRVDEISAEFDSDPRASYFRQAESGMYVRMALLAMVMGRC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHWGI010001326
EMBL· GenBank· DDBJ
KAK3928308.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp