A0AAE0WC02 · A0AAE0WC02_9BIVA

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site14-19ATP (UniProtKB | ChEBI)
Binding site40a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site62-64a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site89-92a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site96CMP (UniProtKB | ChEBI)
Binding site130ATP (UniProtKB | ChEBI)
Binding site137a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site148a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site176ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      CHS0354_011326

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CHS0354
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Ambleminae > Lampsilini > Potamilus

Accessions

  • Primary accession
    A0AAE0WC02

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region34-64NMPbind

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    21,697
  • Last updated
    2024-05-29 v1
  • Checksum
    AE02CB3E4B6759AE
MAKYNVVFVLGGPGAGKGTQCEKIVKHFGFVHLSAGDLLREERQRPGSQYGEEIETHIRNGTIVPVQITCSLLRRAMEESGKNNFLIDGFPRNKDNLDGWNKAMTGVAGVRLVLFFNCSEEVCISRCLSRGEAGSGRSDDNIQSLTKRIQTYHNSTMPIIDHYRGLNLVREIHGEKSPDEVFEDVKQVFAELKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEAOA010000699
EMBL· GenBank· DDBJ
KAK3609061.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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