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A0AAE0RME5 · A0AAE0RME5_9BIVA

Function

function

Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentprotein phosphatase type 1 complex
Molecular Functionprotein phosphatase regulator activity
Biological Processpositive regulation of phosphoprotein phosphatase activity
Biological Processresponse to endoplasmic reticulum stress
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein DP71L
  • Alternative names
    • MyD116 homolog

Gene names

    • ORF names
      CHS0354_016299

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CHS0354
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Palaeoheterodonta > Unionida > Unionoidea > Unionidae > Ambleminae > Lampsilini > Potamilus

Accessions

  • Primary accession
    A0AAE0RME5

Proteomes

Expression

Keywords

Interaction

Subunit

Interacts (via C-terminus) with host PPP1CB.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias259-282Basic and acidic residues
Region259-294Disordered
Region466-493Disordered
Compositional bias476-490Basic and acidic residues
Compositional bias511-526Basic residues
Region511-543Disordered
Compositional bias527-543Polar residues
Domain581-729Protein phosphatase 1 regulatory subunit 15A/B C-terminal

Sequence similarities

Belongs to the PPP1R15 family.
Belongs to the asfivirus DP71L family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    735
  • Mass (Da)
    83,526
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    E430C7CE7275515B92846CD468E640C4
MSSVGPCYQDQAERSQQKESCAFGHERKHYRTMEPILGFDSTVEVTSYQHNYRVPNSGLGKSENVLEKLNEITCVASNWFNNVCPKQTSRHLAKDSEATIPTFVRDFFNNNCGITADKRKMDYTSGCGNIGSESLSTVREWGSPYQTKNITRHYCSKRGHMDQKQIPLYPSNMFKNGFLSSFVRSHFPPTNVHHRMDKSKESQNHTTHFCKHQCVMQDIQLEKLAEEAKLKPYNTKLRLKALMGQKCLHCQKNMEGQTDDHAVTKEELDVSSEKRVDRSTGNRKASSQRTSDDQIRISMETSDNTVTRKDVHDVFWKHIGIDKQIVGDGMNLKQTCSSPVNKSMETSDIMMSEAKEDGIVNKIEKDSPIDWFEYSCAQGGIMPISDNVIQPSLPVKISKPIDTHVVTCDSDSQTIKSCEKRNEKGESKLAIPCSWSCVEELPNFAKTPEVAFENNSLITSKSDCKIQNSVSGDSSSNEIEDKEGVSADNSKKTSDNDISCVLYIRKCSASKKTRPSSKKRRRQKAKLQQVPQNCRDNPAKEETLSGSKSLAFMLGMDSSPINSHFTHSFIMSFDDGDSDWSDSDDFDCSPEETGKDELCELQNSFGLMNLRVSCMNGSEKKSKSHSESSPEECSKRDLDAINMSWKINIPLNDRPTKQELNRRKVHFANDKNLVTLHPMIAWSYAYATARKGPWEEYARDRNRFQRRIQETECILAPILKHDHRSTIYKNYFEAE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias259-282Basic and acidic residues
Compositional bias476-490Basic and acidic residues
Compositional bias511-526Basic residues
Compositional bias527-543Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEAOA010001007
EMBL· GenBank· DDBJ
KAK3576142.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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