A0AAD9VPW4 · A0AAD9VPW4_9HYME

  • Protein
    Double-strand break repair protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site128Proton donor

GO annotations

AspectTerm
Cellular ComponentMre11 complex
Cellular Componentsite of double-strand break
Molecular Function3'-5'-DNA exonuclease activity
Molecular Functionmanganese ion binding
Molecular Functionsingle-stranded DNA endodeoxyribonuclease activity
Biological Processdouble-strand break repair via homologous recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processmeiotic DNA double-strand break formation
Biological Processmitochondrial double-strand break repair via homologous recombination
Biological Processmitotic G2 DNA damage checkpoint signaling
Biological Processmitotic intra-S DNA damage checkpoint signaling
Biological Processtelomere maintenance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Double-strand break repair protein

Gene names

    • ORF names
      KPH14_004671

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GBR_01_08_01A
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Vespoidea > Vespidae > Eumeninae > Odynerus

Accessions

  • Primary accession
    A0AAD9VPW4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain292-473Mre11 DNA-binding
Region526-669Disordered
Compositional bias548-567Acidic residues
Compositional bias611-627Polar residues
Compositional bias628-642Basic and acidic residues
Compositional bias643-669Polar residues

Sequence similarities

Belongs to the MRE11/RAD32 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    669
  • Mass (Da)
    76,546
  • Last updated
    2024-05-29 v1
  • Checksum
    8DAAF50434D38618
MSLKRDSDTFKILVATDIHLGYQYDRNKGQLLYDSFATFEEILQYGKQYEVDFVLLGGDLFHDTKPSQTALIECMDLLRKYCFGPGDVKMEFLTDPNIAFEHCRFKTANYEDPNININMPVFTIHGNHDDPSFSNVGSIDILSVSGLINYFGKCTTLDKVTVEPIVLKKGSTHIALYGLSYINDQRLNRLIKHCKLKLKLPEDNAEKCFNIFVLHQNRIQHTQSDYVPENKLPPFLHLVIWGHEHECLITPEQVTDQAYYISQPGSSIATSLCESEAKPKYVGLLHVNGLEFKMKKLKLNTVRPFVFETISLHNNPQIEQKKKEKRTSSNVNIISEYVDSYIESELMSEARKQLTGHPKQPKEPLIRLRLLYNDEADIFETAGLSQKYCDKVANPMGMIRFRKAADSYSKSTKHSTIDASLDDFSEKFQFDDDESGWTQSVQESIKEYFDAEENKDLLNVLSVTGLNETLSRYIIKADEDVIQDVIENQVNKIKEYVKEQHVEKPEEIMNKVKEYRDTRIEAEENERQDVVNFLNNRSSKSSTREMCNDDEDDENDPVISDNNDDDNDDERISSKVTRSSAKGNARARGRARGRAASSRGTARSRGAKTDVTDKNTMNSLQQSSFLVRDKEKQIEKKKQSSLNQHKGYVSLSQARTPTKPTFINSSDSD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias548-567Acidic residues
Compositional bias611-627Polar residues
Compositional bias628-642Basic and acidic residues
Compositional bias643-669Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAIFRP010000031
EMBL· GenBank· DDBJ
KAK2582334.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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