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A0AAD9T8N5 · A0AAD9T8N5_EUCGR

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site120Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site137Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site185Proton donor/acceptor
Binding site185Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • ORF names
      EUGRSUZ_L03428

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Myrtales > Myrtaceae > Myrtoideae > Eucalypteae > Eucalyptus

Accessions

  • Primary accession
    A0AAD9T8N5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain66-189VOC
Domain195-319VOC

Sequence similarities

Belongs to the glyoxalase I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    36,408
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    C1432311ADE494ECC445C6858841B59F
MCHDLKSFWGISPAIPQSQVLGVKASELLRPAESTTKTNNIGNVAEMNSNLTEDSALRWAKKDKRRMLHAVYRVGDLDKTIKFYTECFGMKLLRKRDIPEERYSNAFLGYGPEDSHFTVELTYNYGTDKYNVGNGLHFGITLDDVAKAVNLVKAKGGKVIKESVLLDGNGKVITYVEDPDGYKFELSEAATTPEPLHHVKLCVGNLDRSINFYKKAFGMDLLSKQDNPEYKYSEVTLGYGPEDTNPVLKLTYNYGVTVYDKGDGYAQIAIGTDDVYKTAEAIKLFDGIIALEPGPLPGINTKITACLDPDGWKSVFVDNVDFLKELE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU851219
EMBL· GenBank· DDBJ
KAK2631087.1
EMBL· GenBank· DDBJ
Genomic DNA
MU851219
EMBL· GenBank· DDBJ
KAK2631088.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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