A0AAD9SY31 · A0AAD9SY31_9HELO
- Proteinxanthine dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1464 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- xanthine + NAD+ + H2O = urate + NADH + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
Note: Binds 2 [2Fe-2S] clusters.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 58 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 61 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 86 | [2Fe-2S] cluster 1 (UniProtKB | ChEBI) | |||
Binding site | 125 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 128 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 169 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 171 | [2Fe-2S] cluster 2 (UniProtKB | ChEBI) | |||
Binding site | 382-389 | FAD (UniProtKB | ChEBI) | |||
Binding site | 466 | FAD (UniProtKB | ChEBI) | |||
Binding site | 476-480 | FAD (UniProtKB | ChEBI) | |||
Binding site | 489 | FAD (UniProtKB | ChEBI) | |||
Binding site | 553 | FAD (UniProtKB | ChEBI) | |||
Binding site | 892 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | |||
Binding site | 923 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | |||
Binding site | 927 | substrate | |||
Binding site | 1005 | substrate | |||
Binding site | 1037 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | |||
Binding site | 1039 | substrate | |||
Binding site | 1206 | Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI) | |||
Active site | 1395 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | FAD binding | |
Molecular Function | iron ion binding | |
Molecular Function | molybdopterin cofactor binding | |
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namexanthine dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Drepanopezizaceae > Diplocarpon
Accessions
- Primary accessionA0AAD9SY31
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 14-104 | 2Fe-2S ferredoxin-type | |||
Region | 241-288 | Disordered | |||
Compositional bias | 247-279 | Polar residues | |||
Domain | 354-543 | FAD-binding PCMH-type | |||
Sequence similarities
Belongs to the xanthine dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,464
- Mass (Da)160,769
- Last updated2024-05-29 v1
- MD5 ChecksumE0CCCD9C969106D96776887FD71B8215
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 247-279 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAUBYV010000007 EMBL· GenBank· DDBJ | KAK2625881.1 EMBL· GenBank· DDBJ | Genomic DNA |