A0AAD9RCL8 · A0AAD9RCL8_9HYME

  • Protein
    NAD-dependent protein deacylase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site62substrate
Binding site65substrate
Binding site100-103NAD+ (UniProtKB | ChEBI)
Active site118Proton acceptor
Binding site126Zn2+ (UniProtKB | ChEBI)
Binding site129Zn2+ (UniProtKB | ChEBI)
Binding site167Zn2+ (UniProtKB | ChEBI)
Binding site172Zn2+ (UniProtKB | ChEBI)
Binding site209-211NAD+ (UniProtKB | ChEBI)
Binding site235-237NAD+ (UniProtKB | ChEBI)
Binding site253NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog 5

Gene names

    • ORF names
      KPH14_003368

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GBR_01_08_01A
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Vespoidea > Vespidae > Eumeninae > Odynerus

Accessions

  • Primary accession
    A0AAD9RCL8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-263Deacetylase sirtuin-type

Domain

In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-62 and Arg-65) that bind to malonylated and succinylated substrates and define the specificity.

Sequence similarities

Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    29,168
  • Last updated
    2024-05-29 v1
  • Checksum
    A8F5030A408C8019
MSCFDQLIEDKLTKRSYKVCNESESGVPTFRGAGGYWRKYQAQSLATPEAFSANPSLVWEFYEYRRTLVSKVKPNKAHEAIAAFQKRLANDGKKVTVVTQNIDGLHQKAGTENVLELHGSLYKTRCLKCHNVSINENIPICPALHGKGIPDPSITSSTIPIEELPRCANIDCKGLLRPDIVWFGENLNESVLNKAYEIVETCDICLVIGTSSIVYPAAMFAPKVANRGVPVAEFNIETTPATRDFQYHFQGPCTITVTEALEP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAD9VKL0A0AAD9VKL0_9HYMEKPH14_003368238
A0AAD9RDW0A0AAD9RDW0_9HYMEKPH14_003368246

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAIFRP010004357
EMBL· GenBank· DDBJ
KAK2577222.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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