A0AAD9K4Q3 · A0AAD9K4Q3_RIDPI
- ProteinE3 ubiquitin-protein ligase parkin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids452 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 421 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | mitochondrion | |
Cellular Component | ubiquitin ligase complex | |
Molecular Function | ubiquitin conjugating enzyme binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | autophagy of mitochondrion | |
Biological Process | negative regulation of protein phosphorylation | |
Biological Process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | protein polyubiquitination | |
Biological Process | regulation of apoptotic process | |
Biological Process | regulation of cellular response to oxidative stress | |
Biological Process | regulation of mitochondrion organization | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase parkin
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Polychaeta > Sedentaria > Canalipalpata > Sabellida > Siboglinidae > Ridgeia
Accessions
- Primary accessionA0AAD9K4Q3
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Forms an E3 ubiquitin ligase complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-72 | Ubiquitin-like | ||||
Sequence: MKFFVNVRYNTCQPVPLEVDRIATILTLKEKIGTRYQLPVDEIRVIFQGRELSDNATFEQCDLGNHSCVHAV | ||||||
Domain | 222-452 | RING-type | ||||
Sequence: LEVPCAACTDTVSLVLVFPCSAGHALCLDCFRTYCITKLNSRAFTQLPDVGYSLECPAGCVNSHIRNPHHFRILGDEQYTRYQRLATEEYVLQNGGVLCPSPGCGAGLLPEGEDNRVVCEKQGGFGCGFEFCRYCHETYHEGDCRTSLLAAISADSGDDYRLDPENALRAQWEKQSKLTIVQTTKACPKCNAPTEKSGGCMHMKCALCCFQWCWICCKEWTRDCQADHWFG |
Sequence similarities
Belongs to the RBR family. Parkin subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length452
- Mass (Da)50,629
- Last updated2024-05-29 v1
- Checksum205BD8423269F12E
Keywords
- Technical term