A0AAD9JJJ5 · A0AAD9JJJ5_9ANNE

Function

function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2E)-decenoyl-[ACP] + H+ + NADPH = decanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-dodecenoyl-[ACP] + H+ + NADPH = dodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexadecenoyl-[ACP] + H+ + NADPH = hexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-hexenoyl-[ACP] + H+ + NADPH = hexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • (2E)-octadecenoyl-[ACP] + H+ + NADPH = NADP+ + octadecanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (2E)-octenoyl-[ACP] + H+ + NADPH = NADP+ + octanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (2E)-tetradecenoyl-[ACP] + H+ + NADPH = NADP+ + tetradecanoyl-[ACP]
    This reaction proceeds in the forward direction.
  • (3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • (3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
  • 3-oxobutanoyl-[ACP] + H+ + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxodecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxododecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxohexanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctadecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxooctanoyl-[ACP] + H+ + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • 3-oxotetradecanoyl-[ACP] + H+ + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP+
    This reaction proceeds in the forward direction.
  • H+ + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H+ + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • H2O + hexadecanoyl-[ACP] = H+ + hexadecanoate + holo-[ACP]
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • H2O + tetradecanoyl-[ACP] = H+ + holo-[ACP] + tetradecanoate
    This reaction proceeds in the forward direction.
    EC:3.1.2.14 (UniProtKB | ENZYME | Rhea)
  • a (3R)-hydroxyacyl-[ACP] + NADP+ = a 3-oxoacyl-[ACP] + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.1.1.100 (UniProtKB | ENZYME | Rhea)
  • a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.59 (UniProtKB | ENZYME | Rhea)
  • a 2,3-saturated acyl-[ACP] + NADP+ = a (2E)-enoyl-[ACP] + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.3.1.39 (UniProtKB | ENZYME | Rhea)
  • a fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
    EC:2.3.1.41 (UniProtKB | ENZYME | Rhea)
  • acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.38 (UniProtKB | ENZYME | Rhea)
  • acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
    EC:2.3.1.85 (UniProtKB | ENZYME | Rhea)
  • acetyl-[ACP] + H+ + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • butanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • decanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.
  • dodecanoyl-[ACP] + H+ + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Molecular Functionfatty acid synthase activity
Molecular Functionoxidoreductase activity
Molecular Functionphosphopantetheine binding
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • ORF names
      LSH36_290g03082

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • P08H-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Polychaeta > Sedentaria > Canalipalpata > Terebellida > Terebelliformia > Alvinellidae > Paralvinella

Accessions

  • Primary accession
    A0AAD9JJJ5

Proteomes

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain1490-1567Carrier
Compositional bias1560-1575Polar residues
Region1560-1579Disordered

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,868
  • Mass (Da)
    205,178
  • Last updated
    2024-05-29 v1
  • Checksum
    65CFF7D0E3694753
MISGRTKPGVTKTLEMIKEHKESIQLQTLLQENANLPPSVHPCRGYTLLNHDSSLLETQECSAEQRPVWFVFAGMGTQWTGMGRDLMCIESFKDSILRSDSVLQPYGLHLYDLLMNSSESAFTNTLNSFVGIAAIQVALVDVLRVLGIKPDGIVGHSVGELGCAYADGGLTAEETVLAAYWRGRCVLEANLPPGGMAAVGLTWEEAHRRCPKGVVPACHNAEDTVTISGPTEDVTKFVEELKQEGIFAKEVKSAGVAFHSYYMSKTAPALLSALKQVIVEKRPRSSCWISSSIPESNWGSELSQTSSAEYHVNNLVSPVLFQEALQHVPRNAITIEIAPHCLLQALLKRSLGSECTFVGLMKRHHQDNLEFLLSSLGKLHLAGVNFNPLSLYPATSYPVPAGTPMVAPLIQWDHDVSWNVPKQEDFMSIGPGGTASCVYEMDASPDSEDHYLDGHVIDGRTLFPAAGLLVLPWRALARIKGYVYTDMAVTFEDVCIHRATIMPKTGDKGQLVWNDNWISFVDTMLQMEVLGLPGRELRLPTRIKAVHIDPTVHRESVTNFDKEKQAIRVLVDNELSTCVAGGVEIIGLHATVAPRRQQTQAAPITEKYTFVPYRQMELGKTDCSLQQYAKLCTKYIKHRMDALLDNGIADKIPNRELFQKVLEQSESCDGVQSEVEQYLIKEKNQYSLLNLIHDVFGLQSDDNFLQKAKTVIEEGRDKLSQDRLLSFMLHPERLKPCLDLALENGKRTKVKVVEFCCRGCSPIYPHVISLLQTQPMLNVEYVLTGPGAAGISDDVPEKYGIRMVPWDGSLDPPHNMVADILVIRNVYVSSVSGLLRNLVGVLAEGGFLLLQEPTTNFSIPLFLGGLTNDLSADDSQGLFNDSAHWEKYLQDLELNVISLLADGILYNTFLCQKQKDVPKNPPVIDVSDVHFSWIEELKVAMINQEKAVDNGRIWLRVQAESPSGVIGLQGDKYTLPDTDSEEFLDLSRKDLVMNVMRDGQYGSYRHLPHLSGISSELLYGSLEQAATVPVAYATAYYALIVRGRIKKGDRVLIHAGSGGVGQAAIAIALNRGCEVFTTCGTGEKQHFLKDRFPQLNDAHIANSRDKTFEWDILKATRGHGVDVVLNSLAGDKLQAGVRLLAQHGRFLEIGKVDLSNNSNLGMGVFLKNVTFHGILLDALFDEGNCEWPEVASLLGKGIEAGVVRPLNTTVYDKEQVEAAFRYMAQGKHIGKVLIKPLPMKIPALGRTTCHPLKSYIITGGLGGFGLELAHWLVQRGAKNLVLTSRSGIRNGYQSRCIRLWRESGVTVTISVSDVSTVEGARQLVREAETLGLVGGIFHLAMVLRDGLMENQSEENFRIVGKTKVIGTINLDKVTRDQCSTDLDWFVVFSSVSCGRGNAGQANYGYSNSIMERICEERVTDGLPGLAVQWGAVGDVGVVLDTMGNNDTVIGGTLPQRIKSCLSTLDKFINQPEPVVSSFVLVERSTKSINQDTASNLLKVIGNILGVKDSSSINQDSTLGDLGLDSLMGVEVKQTLERDYDLSLPMQEIRALTMNKLKGISGDMPSSKSPTQSKKESPAVDVMKVSKRYNPKQIMPIKTVIQLTEGDQSHSPLFVIHPIEGVLVSLQSVMKKVRQPVYGLQCTKEVPSGSVVELSTYYIQKMKEIQPKGPYYLAGYSFGACVAMEMALQLQAEDEDVKRLILLDGSHLYAAVHIQRFKSKIAPGSKAAAEAEAMCAFLHQFMTIDYNKLTTEMASLPDYKSRIQAAVDHLLASNQLSDSEDLTSAADSFYNKLVMADAYSLKGKLKESTEVVLIKAVEADPDVKSLGSDYGLSEVCSGHISIHEVLGDHESFIEGDGAPVVADIINSLL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1560-1575Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAODUP010000290
EMBL· GenBank· DDBJ
KAK2153658.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp