A0AAD9GKR8 · A0AAD9GKR8_BABDI

  • Protein
    ATPase ASNA1 homolog
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site, active site.

135750100150200250300350
Type
IDPosition(s)Description
Binding site34-41ATP (UniProtKB | ChEBI)
Active site63
Binding site234ATP (UniProtKB | ChEBI)
Binding site261ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGET complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processpost-translational protein targeting to endoplasmic reticulum membrane
Biological Processprotein insertion into ER membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATPase ASNA1 homolog
  • EC number
  • Alternative names
    • Arsenical pump-driving ATPase homolog
    • Arsenite-stimulated ATPase

Gene names

    • ORF names
      X943_001432

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1802A
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    A0AAD9GKR8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-290Anion-transporting ATPase-like
Domain296-350Anion-transporting ATPase-like

Sequence similarities

Belongs to the arsA ATPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    40,558
  • Last updated
    2024-05-29 v1
  • Checksum
    BD615E12F638C0ED
MEITSDTESIAHVRNDIQNLVNQKSLQWIFVGGKGGVGKTTVSSSIATILAESRESVLLLSTDPAHSLSDAFGQKFTYEPRLINGFNNLYAMELNTAQIVDGFDGLKESHSFLQTIPDILKMLPGLDEALSFVELMQSVQSRRFSVIVFDTAPTGHTLKFLKLPEVLDKLADAFMKMENVMGSLMKLMSSMTAQQMSQTEMFDKIKLLRSMINRTHDQMRDPSLTTFVCVCIPEFLSVYETERLIQDLARGDIDCSYIVVNQVLKHIDIANLIEDAWAKLDDEQQETMKCFFDRVREHQSAHNSRVEVQRKYLQDIKDLYQDDFNIVAIPQNKQEVRGKEALVEFAKTLLQHNPLPL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHBMH010000003
EMBL· GenBank· DDBJ
KAK1940285.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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