A0AAD9GK15 · A0AAD9GK15_BABDI

  • Protein
    Probable ATP-dependent 6-phosphofructokinase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site204ATP (UniProtKB | ChEBI)
Binding site268-269ATP (UniProtKB | ChEBI)
Binding site297-300ATP (UniProtKB | ChEBI)
Binding site298Mg2+ (UniProtKB | ChEBI); catalytic
Site299Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site338-340substrate
Active site340Proton acceptor
Binding site385-387substrate
Binding site446substrate
Binding site548-551substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • ORF names
      X943_004088

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1802A
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    A0AAD9GK15

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region48-72Disordered
Compositional bias57-71Polar residues
Domain196-450Phosphofructokinase
Domain776-1014Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,342
  • Mass (Da)
    149,449
  • Last updated
    2024-05-29 v1
  • Checksum
    6569AEA6156CE710
MAYEDLLDLSGRNNKDVIRHRNGEISCDVAGASEEVVARQAQEAVDRRRDRFRISSRSTSSHQSESRHRSVSPGPRIQFLKLATLEAESALKEGFDVAKGLYLFAPLSFVLGDGLKRMNSCYTSKSVCQDRLVNHDVELPSLLQFDHHVLEEHDTSGEDMTDFDELSKVLCHIAKERMVSVQPQVLCSDSSHRILKIGLVLSGGPAPGGHNVIAGIFDYMYLRNTQSQMIGFHGGLDGLLNRHHEIITPHAMDQFRNMGGFNMLLSGRGKISGASDLDKAVEAVNELDLDGLIIVGGDGSNSNAAILANHFAGRANVTNPDGKPALKKPCCVVGIPKTVDGDVKSHNIEISFGFDTAARTYSELIGNLCTDASSTQYTYHFIRVMGRSASHLALECGMQTHPNVVLIGEEVKRKQQSLSAIVDDIVDLMEKRHSMGKPYGVVLIPEGLIEFIPEIDILIGELNEILTKADGPVTYLAPEKLNKSRATWESLPESIREQLLMDREATGYVMLAKIATERLLLMLVERRIAERNLPHLSSLTFMSHYFGYEGRCAIPSRFDSAYCYALGYNAGVLINARRNGYMSVIRDLKSPVSEWVPLGVPFIHLMRMIDLGGRRVPAIRKTLLDLDGDLFKVFEKVRDLWAYHDLYRSPGPIQLFSDGVLHCFSISNPTVEDLIGDFKPGDDVDRRFLLHRRLDCMSPLQRKLLNLRPRIPAICTDPRARMKMFKQVLSHDPYTRNQIVLNYPYMTRKVHFNLYEVVGDYSHSDMRDPVRSMPLKVGVVVLSKQAPGVLNVIWGLHERLSIYGSKCFAFNGGKGLVDCDYIELCANDFDLFRNQGGLEMVHRSRVHYFHDPKHWGPALQTCTKLGLDGLVILGDEVAMTQAALLTEYFLSKNSQICIVGVPVAGSNGLACQLIESCVGFDSNAQLYASLVGNVLTDAVSMPKYWHFVKILGRYPSLEVLECALQTHPNFIIIAEEYGSADKTLFDVVRDIADAVCKRAKAGKNFGTVLIPDHLVLHLPNTKSMLTELREVLLEAAAAGKRQEAVDSFLNYSKDSKDASEWVKKITPWSLGVFTSLPLYIRTELLNFGTEVALERLDIEIMLAKMVKEELNLRKAKGEYNGKYAAVTHYFGYQGRCCMPSEFDCSLAFAYGHIAGIAIENRLTGCCCSIRGLSGAVKDWKMFAIPLTSLMKVDPNILQVISLNEFKKGELPVIPSSTVDLKSKAFKKMTMARKTWLLDDLFINPGPIQYNGSVATQSMVLINEHAEYYHMLNGVERFLGILQNTCKFGVSEEFLNHAFVQLWGLIKVTQSPGELVNLAQHIKSDDDEATTPSASPSSINSYV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias57-71Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHBMH010000007
EMBL· GenBank· DDBJ
KAK1939867.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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