A0AAD9GJN7 · A0AAD9GJN7_BABDI

  • Protein
    Pre-mRNA-processing factor 19
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentPrp19 complex
Cellular ComponentU2-type catalytic step 1 spliceosome
Molecular Functionubiquitin protein ligase activity
Biological ProcessDNA repair
Biological ProcessmRNA splicing, via spliceosome
Biological Processprotein K63-linked ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pre-mRNA-processing factor 19
  • EC number

Gene names

    • ORF names
      X943_002307

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 1802A
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    A0AAD9GJN7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain, coiled coil, repeat.

Type
IDPosition(s)Description
Domain1-71U-box
Coiled coil116-143
Repeat245-286WD
Repeat346-377WD
Repeat463-496WD

Sequence similarities

Belongs to the WD repeat PRP19 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    496
  • Mass (Da)
    54,634
  • Last updated
    2024-05-29 v1
  • Checksum
    AADEE34810F5E135
MALICSISGVEPEEPCLSKTGYVFERRLIEKHLEESQTCPVTGEQLTVADLTPIKCNKPVKPRPATATSIPGLLSLFQSEWDALALETYKLRQHAGTIRKQLCHSLYEHDAATRVIARLIKERDRALKQVEMQQQQLLEFRKNYDAAAIEVGLDEGSISRIEELAKALMTERKKRDVSQYMSVDKIAMFRQTGDYRTHSSTTPGILSVALDFYSAQAGRRACFTGGADGSIIYFDLDSGKTLTRLTNHMKAVNSVVAHPLSHILISGSDDKTMRVWHASDMSDNDQDFRCSHVVRSSKAAVSSVSLHASGEYFMGCSSDGLWHLIELESGRVVKVCRDIPSPCHNIQFHPDGLLASGSGSDGNVHIWDLRTQALTSSLSHQSGGSLSYIDFSENGYHMASVTQKGQIHLWDLRKSKVFASADCNVSPSVIKFDKSGTTLAVGSTKVELFSLVDKTTLNAAGTLEGHSGYLTDLEFGFNSQFLLTSCKDKSLRVFSP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHBMH010000007
EMBL· GenBank· DDBJ
KAK1939685.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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