Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0AAD9FPU9 · A0AAD9FPU9_PAPLA

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Ni cation (UniProtKB | Rhea| CHEBI:25516 )

Note: Binds 2 nickel ions per subunit.

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site399Ni2+ 1 (UniProtKB | ChEBI)
Binding site401Ni2+ 1 (UniProtKB | ChEBI)
Binding site482Ni2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site482Ni2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site484substrate
Binding site511Ni2+ 2 (UniProtKB | ChEBI)
Binding site537Ni2+ 2 (UniProtKB | ChEBI)
Active site585Proton donor
Binding site625Ni2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenturease complex
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease
  • EC number
  • Alternative names
    • Urea amidohydrolase

Gene names

    • ORF names
      DB88DRAFT_469260

Organism names

Accessions

  • Primary accession
    A0AAD9FPU9

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue482N6-carboxylysine

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain394-832Urease

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    832
  • Mass (Da)
    89,858
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    A865DB1069797327473E05F8D6CA8AAA
MRLLPREQDKLVLYTVGSLAQRRLARGLALNRSETIALIAFQLHEFIRDGRHTVAELMDLGKKMLGRRHVMHGVPEAIHDIQVEGTFPDGTFLVTVHDPICSDDGDLNNALYGSFLPVPSSDLFPLAPPTSDPLPGAVVCLPTPIQLNPERKRILVQVHNKGDRPVQVGSHYPFLEVNPCLVFDRVKAYGTHLDIAAGTAVRFEPGETKTVALVEIGGLKILSGGSGLATGRFDESLRGGIERIVLEKGFGHKDQPHVQIAPVPEMNREVYASMFGPTVGDKVRLGDTSLWVEIEKDYTVYGDECKFGGGKVLRDGAGQASGRKDSEVLDLVISNALVIDWSGIYKADIGVKNGLIVGIGKAGNPDTMNGVHPKMIVGSNTETIAGEKHIITAGALDVHVHYICPQLWQEAMANGITTLVGGGTGPADGSKATTCTSSEFYMKTMMVATDSIPLNFGFTGKGNDSGLPGIRDIVEAGACGLKLHEDWGSTPEAIDRALTVGDEYDVQVNIHTDTLNESGYVESTLAAIKGRTIHTYHTEGAGGGHAPDIIVVVEHPNVLPSSTNPTRPYALNTLDEHLDMLMVCHHLDKSIPEDIAFADSRIRAETVAAEDALQDTGAISMISSDSQAMGRIGEVVSRTWRTASKMRDVRGTLEGDGEKKDNERVKRYVAKYTINPAITHGMSHIIGQVAEGCLADLVMWKPENFGAKPELVLKGGVIAWSNIGDANGSIPTVQPYNAKPMWGAEPKAAALNSITFASQISVERGIKETYGLGKRVEGVKHCRDIGKKDMKWNDSMPKMKVDPETYEVFADGVLCDAPPATELPLTTKHFIF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAODAN010000012
EMBL· GenBank· DDBJ
KAK1920967.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help