A0AAD8ZY78 · A0AAD8ZY78_9PEZI
- ProteinPalmitoyltransferase PFA4
- GenePFA4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids444 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Catalytic activity
- L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 125 | S-palmitoyl cysteine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | protein palmitoylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase PFA4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Glomerellales > Glomerellaceae > Colletotrichum > Colletotrichum gloeosporioides species complex
Accessions
- Primary accessionA0AAD8ZY78
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | |||
Transmembrane | 48-65 | Helical | |||
Transmembrane | 143-162 | Helical | |||
Transmembrane | 182-204 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 94-221 | Palmitoyltransferase DHHC | |||
Region | 381-427 | Disordered | |||
Compositional bias | 411-425 | Acidic residues | |||
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)50,815
- Last updated2024-05-29 v1
- ChecksumB28FD2AA84806569
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 411-425 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAQOWY010000966 EMBL· GenBank· DDBJ | KAK1837906.1 EMBL· GenBank· DDBJ | Genomic DNA |