A0AAD8YSG1 · A0AAD8YSG1_9TELE
- ProteinSH3 domain-binding protein 5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids946 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
Catalytic activity
- biocytin + H2O = biotin + L-lysine
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | hydrolase activity | |
Molecular Function | SH3 domain binding | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSH3 domain-binding protein 5
- Short namesSH3BP-5
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionA0AAD8YSG1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with RAB11A on cytoplasmic vesicle membranes.
Keywords
- Cellular component
Interaction
Subunit
Interacts with GDP-bound and nucleotide-free forms of RAB11A.
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-41 | Disordered | ||||
Sequence: MDDSVKGNKSDGETESPEDEEVDPRIQGELEKLNQSTDDIN | ||||||
Coiled coil | 89-130 | |||||
Sequence: ARQAQVEAQRATQEFQRAIEILRAAKETIALAEERLLEEDSR | ||||||
Coiled coil | 168-223 | |||||
Sequence: YTAAVNHVRQLEKKLKRAVNKSRPYFELKAKYYLQLEQLKRRVDECQAKLTQAKAD | ||||||
Compositional bias | 283-338 | Polar residues | ||||
Sequence: EESCNGVTSEEDPEMQSTCSLSSNSTPVNLPRPYLATPSSPYPSSSSSSSSTTPSP | ||||||
Region | 283-351 | Disordered | ||||
Sequence: EESCNGVTSEEDPEMQSTCSLSSNSTPVNLPRPYLATPSSPYPSSSSSSSSTTPSPRPSDPELPSPDSL | ||||||
Domain | 420-671 | CN hydrolase | ||||
Sequence: ILGACVLAIHLIGAEETLYVAAVYEHRVILNPRSGVPLRRRAALEHMEKNLHAFAEQAALAALQVLRRLSCMARKNRLFLVANMPDRQPCSRASDPLCPPDGQYQFNTDVVFSDNGTLVARYHKQNLYFEAAFDTPLRNKYVTFTTPFAGRFGVFTCFDILFREPAVTLVRDMGVRQLVYPTAWMNQLPLLAAVQFQRSFSYSAGVTLLAANVRAAALGMTGSGIFTPWEAVYHHDSTEGEQGRLLVSRVPV | ||||||
Region | 909-946 | Disordered | ||||
Sequence: AGEGGEELGVVTDKRGGHNDASRGRYSLKDRSTQNPLF | ||||||
Compositional bias | 916-935 | Basic and acidic residues | ||||
Sequence: LGVVTDKRGGHNDASRGRYS |
Domain
The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.
Sequence similarities
Belongs to the SH3BP5 family.
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length946
- Mass (Da)104,771
- Last updated2024-05-29 v1
- ChecksumB01B85E0996B26BD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 283-338 | Polar residues | ||||
Sequence: EESCNGVTSEEDPEMQSTCSLSSNSTPVNLPRPYLATPSSPYPSSSSSSSSTTPSP | ||||||
Compositional bias | 916-935 | Basic and acidic residues | ||||
Sequence: LGVVTDKRGGHNDASRGRYS |
Keywords
- Technical term