A0AAD8BP98 · A0AAD8BP98_BIOPF
- ProteinATP-binding cassette sub-family B member 6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids836 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ATP + H2O + heme b(in) = ADP + H+ + heme b(out) + phosphateThis reaction proceeds in the forward direction.
CHEBI:30616 + CHEBI:15377 + heme b (in)CHEBI:60344= CHEBI:456216 + CHEBI:15378 + heme b (out)CHEBI:60344+ CHEBI:43474 - ATP + H2O + pheophorbide a(in) = ADP + H+ + pheophorbide a(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + protoporphyrin IX(in) = ADP + H+ + phosphate + protoporphyrin IX(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin I(in) = ADP + H+ + phosphate + uroporphyrin I(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin III(in) = ADP + H+ + phosphate + uroporphyrin III(out)This reaction proceeds in the forward direction.
- ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Molecular Function | ABC-type heme transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | heme binding |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Panpulmonata > Hygrophila > Lymnaeoidea > Planorbidae > Biomphalaria
Accessions
- Primary accessionA0AAD8BP98
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-50 | Helical | ||||
Sequence: VIVFGFVFLTGILQCVMYSKY | ||||||
Transmembrane | 70-90 | Helical | ||||
Sequence: VFTVLLMLEALAHMILSDIYL | ||||||
Transmembrane | 96-118 | Helical | ||||
Sequence: LGYQVLVACAIISAYIVSWWLLA | ||||||
Transmembrane | 134-153 | Helical | ||||
Sequence: GIVLLLFYVLVFIRETLMFL | ||||||
Transmembrane | 173-192 | Helical | ||||
Sequence: LAFFILRYFLITSLLILGFI | ||||||
Transmembrane | 238-257 | Helical | ||||
Sequence: LLLQVTVGICIILLAAGRAV | ||||||
Transmembrane | 289-310 | Helical | ||||
Sequence: YILIFITLIFLKGGGTGTSGLL | ||||||
Transmembrane | 367-390 | Helical | ||||
Sequence: LLSYLVFQIFPTIADIIIAIVYFI | ||||||
Transmembrane | 396-416 | Helical | ||||
Sequence: LFGLIVFISMACYLAATIIVT | ||||||
Transmembrane | 487-506 | Helical | ||||
Sequence: LINTVGLAAGSLLCAWAVVH | ||||||
Transmembrane | 518-539 | Helical | ||||
Sequence: YVLFGTYITQLYVPLNWLGTYY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 246-544 | ABC transmembrane type-1 | ||||
Sequence: ICIILLAAGRAVNVFVPIYSKLIVNSLAYDPSKPGEVMEFRWDYILIFITLIFLKGGGTGTSGLLNDTRSLLWIKVQQYTTQAIQIKLFSHLHGLSLRWHLGRKTGEVLRVVDRGTNSINSLLSYLVFQIFPTIADIIIAIVYFITFFNYLFGLIVFISMACYLAATIIVTEWRTKFRRLMNQKDNEANAKAVDSLLNFETVKYYEASDWETERYRKAILEYQVAEWHSNASLSLLNSVQNLINTVGLAAGSLLCAWAVVHGVNDLHLTVGDYVLFGTYITQLYVPLNWLGTYYRMIQQ | ||||||
Domain | 578-812 | ABC transporter | ||||
Sequence: IQFKNVCFSYEPSKAILKNISFTVPAGHTYALVGHTGCGKSTIVRLLFRFYDVNSGTILIDGQDISQITQKSLRKSIGVVPQDTVLFNSDIRYNIRYGKITATDTEVEEAARAAEIHDRILTFPKKYETVVGERGLKLSGGEKQRVAIARTLLKAPAIVLLDEATSALDTKTERSIQSSLARVCENRTTIIVAHRLSTIIHSHQIIVLDEGEIKEMGTHQDLLDMDGVYAEMWRQ | ||||||
Region | 816-836 | Disordered | ||||
Sequence: KQGQETENNTSSNGTTTADNS |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length836
- Mass (Da)94,510
- Last updated2024-05-29 v1
- Checksum43C44DEE004047C3
Keywords
- Technical term