A0AAD5UAF1 · A0AAD5UAF1_9FUNG

  • Protein
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site1180Zn2+ (UniProtKB | ChEBI); catalytic
Active site1181
Binding site1184Zn2+ (UniProtKB | ChEBI); catalytic
Binding site1190Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Molecular FunctionATP binding
Molecular Functioninositol heptakisphosphate kinase activity
Molecular Functioninositol hexakisphosphate kinase activity
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • EC number

Gene names

    • ORF names
      HK103_001384

Organism names

  • Taxonomic identifier
  • Strain
    • PLAUS21
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Chytridiomycota > Chytridiomycota incertae sedis > Chytridiomycetes > Rhizophydiales > Terramycetaceae > Boothiomyces

Accessions

  • Primary accession
    A0AAD5UAF1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond1214↔1219

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain137-347ATP-grasp
Domain1025-1220Peptidase M12B

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,220
  • Mass (Da)
    137,653
  • Last updated
    2024-05-29 v1
  • Checksum
    111719DD74C98E31
MDDEKKCSLLLNSGTIGICAMDTKSRSKPMRNILDRLLASGDFSLIIFGDKVILDEPVDHWPLCDFLISFFSTGFPLEKAIDYVKLRKPVCLNDLPMQQLLLDRRLVLTMLDAVGVPTPKRLVTWHKDAPTLTKEVKMKARRIGFDVDRYINATITAKMVSSEEIQVENDSLKKPFVEKPVSGEDHNIYIYYSKEEGGGIRKLFRKKGNKSSEYFKEESDIRCDGVNSYIYEEFMQVDNAEDVKVYTIGQHYSHAETRKSPVVDGVVRRNAEGKEIRYVTELSPEEVDIARKVCVTFGQTVCGFDLLRANGKSYVIDVNGWSFVKGNQDYYDESASRIRKIFLNEVSRRGNKLVRQQTFSSKGQWNMKAFLSVMRHADRTPKQKVKFFFETQPFLDLVKGCEDELVYKTMDKFKIVMDTVKYCIDNSIGDVDALKQIDNILEHKGKLSGTKIQLRSIFEKGTKNLKKMQLIIKWGGLFTHAGYLQSKDLGENLRTDLNIINKDLIQDLKVLSSSEKRVIDTAETFCKALLDKDIPSGLIVINKEMLDDSNAAKEQTDYVKSKLQHILNPDYHAIPPSVFVMPEGWTDFAEPVRTMIKLMKRMRIIMVENLKVPRAKVEFCCFENEQLFLERWDKLFKEFCDVEHNKFEPSKISELYDALKFDLLHNREFLYYTFKHDDENLVQSLCVQSKALFDIIGPHEFGIENKEKLEIGKTNTRFLLNSIHSELVTASISPNALTRLYFTKESKVYCLLNVVLLNGLKTKVIPTDIAELDYLTQITFELYERTGGIDDDRNEPEFSVRIGLSPGAHDPNLIELQLDSSHALSVQPLNPPIRTYDFVTKPTIYKTNGKLHLKFKSFNSTFHAELESSSLNLNGYAEIHGDDGVQFLPLPYHTVYNGVMKEDNQIVKGSSAQIVITSQNPLTMEGSIIMDTNYHIKQINQYKRAQRRADVEVASPYSRDPEDYLSDFILIKEDYGVIEKHDHISHLIKRNSFSTCGTDTSSYTGKSSKFGAVKDSTSCPLPNKKVLLMGVAADCSYVQAKGGVSQALQSILSNWNSATQTYESTFNVQLGVGKVMIQQSCSADNSLTWNVDCSNPQFTISNRLSAFAQWRGTLGDDGMGLWHLMTQCSTQPAVGIAWLSTLCQQNAVAQSDPSGSGGTVYVSGVGVSSIVPTEWKVVAHEIGHNFGAIHDCTSSTCSASGASNVCSPCSPCDCNSQFCN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADGKB010000136
EMBL· GenBank· DDBJ
KAJ3252585.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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