A0AAD5UAF1 · A0AAD5UAF1_9FUNG
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1220 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Molecular Function | ATP binding | |
Molecular Function | inositol heptakisphosphate kinase activity | |
Molecular Function | inositol hexakisphosphate kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Chytridiomycota > Chytridiomycota incertae sedis > Chytridiomycetes > Rhizophydiales > Terramycetaceae > Boothiomyces
Accessions
- Primary accessionA0AAD5UAF1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 1214↔1219 | |||||
Sequence: CNSQFC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 137-347 | ATP-grasp | ||||
Sequence: KMKARRIGFDVDRYINATITAKMVSSEEIQVENDSLKKPFVEKPVSGEDHNIYIYYSKEEGGGIRKLFRKKGNKSSEYFKEESDIRCDGVNSYIYEEFMQVDNAEDVKVYTIGQHYSHAETRKSPVVDGVVRRNAEGKEIRYVTELSPEEVDIARKVCVTFGQTVCGFDLLRANGKSYVIDVNGWSFVKGNQDYYDESASRIRKIFLNEVS | ||||||
Domain | 1025-1220 | Peptidase M12B | ||||
Sequence: KVLLMGVAADCSYVQAKGGVSQALQSILSNWNSATQTYESTFNVQLGVGKVMIQQSCSADNSLTWNVDCSNPQFTISNRLSAFAQWRGTLGDDGMGLWHLMTQCSTQPAVGIAWLSTLCQQNAVAQSDPSGSGGTVYVSGVGVSSIVPTEWKVVAHEIGHNFGAIHDCTSSTCSASGASNVCSPCSPCDCNSQFCN |
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,220
- Mass (Da)137,653
- Last updated2024-05-29 v1
- Checksum111719DD74C98E31
Keywords
- Technical term