A0AAD5L8I0 · A0AAD5L8I0_PYTIN

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

133550100150200250300
TypeIDPosition(s)Description
Binding site78Mg2+ 1 (UniProtKB | ChEBI)
Binding site110Mg2+ 1 (UniProtKB | ChEBI)
Active site186
Active site226Proton donor/acceptor
Binding site226Mg2+ 1 (UniProtKB | ChEBI)
Binding site228Mg2+ 1 (UniProtKB | ChEBI)
Site228Transition state stabilizer
Site298Important for catalytic activity
Binding site323Mg2+ 1 (UniProtKB | ChEBI)
Active site324Proton acceptor
Binding site324Mg2+ 1 (UniProtKB | ChEBI)
Site324Interaction with DNA substrate

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA repair nuclease/redox regulator APEX1
  • EC number
  • Short names
    APEN
    ; REF-1
  • Alternative names
    • APEX nuclease
    • Apurinic-apyrimidinic endonuclease 1
    • Redox factor-1
  • Cleaved into 1 chains

Gene names

    • ORF names
      P43SY_005417

Organism names

Accessions

  • Primary accession
    A0AAD5L8I0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-41Disordered
Compositional bias9-26Basic residues
Domain76-324Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    38,086
  • Last updated
    2024-05-29 v1
  • Checksum
    4DF63390C49F685A
MPPPPTTTTRSRRRKKRKRPPVTTKKGKKKNAGDGNWSRPARVEALADDIKDKIAAFPKFDGVASRSPDAECKIVAWNVNGLRALLKKDDSIHFRAYAAQEDADVLCLSEIKIDRNEVEKLEDVLPQYEHQFWSSAAKKGYSGTAIFSKIKPLSVKDEIIVEGDAPEDEGRFLALEFATFWLVHTYVPNAGQKLDRLSYRTEKWDKAMLRMLKDLEASKPVVWCGDLNVAHQEIDIHDPKGNRNKSPGFTDAERDSFGEILASGFVDTFRHLHPEQQQYTYWSYRFNARAKNKGWRLDYFVVSQSLLARVHQSFVRDAITGSDHVPIGLELRGAT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias9-26Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAKCXM010000822
EMBL· GenBank· DDBJ
KAJ0391818.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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