A0AAD5E1C9 · A0AAD5E1C9_UMBRA

Function

function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentnucleus
Cellular Componentspindle
Molecular FunctionGTP binding
Molecular Functionhydrolase activity
Molecular Functionstructural constituent of cytoskeleton
Biological Processmicrotubule cytoskeleton organization
Biological Processmitotic cell cycle
Biological Processnuclear division
Biological Processnuclear migration by microtubule mediated pushing forces

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin alpha chain

Gene names

    • ORF names
      K450DRAFT_263799

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AG
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Umbelopsidomycetes > Umbelopsidales > Umbelopsidaceae > Umbelopsis

Accessions

  • Primary accession
    A0AAD5E1C9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain47-244Tubulin/FtsZ GTPase
Domain246-391Tubulin/FtsZ 2-layer sandwich
Region430-449Disordered

Sequence similarities

Belongs to the tubulin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    49,822
  • Last updated
    2024-05-29 v1
  • Checksum
    62A6BB15F8BC8A34
MREVISIHVGQAGVQIGNACWELYCLEHGINPDGHLPEGEGNGDNSFDTFFSETSSGKHVPRTVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKELVDVVLDRIRRLADNCTGLQGFLVFHSFGGGTGSGFGALLLERLSVDYGKKSKLEFSVYPAPQVSTAIVEPYNSILTTHTTLEHSDVAFMVDNEAIYDICRRNLDIERPTYSNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVTYAPIISAAKAGHENLSVSEITNSCFEPNNQMVKCDPRHGKYMACCLLYRGDVVPKDTNAAVAAIKTKRTIQFVDWCPTGFKIGINYQAPTVVPNGDVAKVSRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGSDSLGYSDAEEVEEY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU621012
EMBL· GenBank· DDBJ
KAI8575004.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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