Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0AAD5CY05 · A0AAD5CY05_AMBAR

Function

function

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)
Binding site601D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)
Binding site95ATP (UniProtKB | ChEBI)
Binding site153ATP (UniProtKB | ChEBI)
Binding site1641D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)
Binding site185-196ATP (UniProtKB | ChEBI)
Binding site1961D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)
Binding site211ATP (UniProtKB | ChEBI)
Binding site281Mg2+ 1 (UniProtKB | ChEBI)
Binding site296Mg2+ 2 (UniProtKB | ChEBI)
Binding site296Mg2+ 1 (UniProtKB | ChEBI)
Binding site2981D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)
Binding site298Mg2+ 2 (UniProtKB | ChEBI)
Binding site3021D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioninositol-1,3,4-trisphosphate 5-kinase activity
Molecular Functioninositol-1,3,4-trisphosphate 6-kinase activity
Molecular Functioninositol-3,4,5,6-tetrakisphosphate 1-kinase activity
Molecular Functionmagnesium ion binding
Biological Processinositol trisphosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol-tetrakisphosphate 1-kinase
  • EC number

Gene names

    • ORF names
      M8C21_001862

Organism names

  • Taxonomic identifier
  • Strain
    • AA19_3_7
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Asterales > Asteraceae > Asteroideae > Heliantheae alliance > Heliantheae > Ambrosia

Accessions

  • Primary accession
    A0AAD5CY05

Proteomes

Subcellular Location

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-89Inositol-tetrakisphosphate 1-kinase N-terminal
Domain114-319Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp

Sequence similarities

Belongs to the ITPK1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    40,697
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    96927CC2D51962CD6C438389EFC64BCE
MAETNPTRFTIGYALLLKKQQSFIQDSLLTLAKQRGIDLIKIDTDKPLVGQGPFDCVLHKLYGDDWRNQLREYLIRYPDSIVIDFPDAIERLHNRISMLDVVEEIEVNDDDDDDTASFGVPKQVVVYEPEKLKDMKVWSEGLGLSLKFPVIAKPLVADGSAKSHKMLLIFSTEGFDKLKTPTVLQEFVNHGGVIFKVYVVGRYVQCVKRKSLPDIDEEKLESLHGSLSFSQISNLTSDERNDDKYYKMMDSEEAEMPPMSLISNIARGLRKAMKLHLFNFDVIRDTKVGNRYLVIDINYFPGYAKMPGYESVLTDFFWDVLNKKEDRFFDCEKELMKLVGNNGGCDEDTGCPNVSSA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAMZMK010006348
EMBL· GenBank· DDBJ
KAI7749497.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help