A0AAD4LQI7 · A0AAD4LQI7_9AGAM

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site156ATP (UniProtKB | ChEBI)
Binding site240ATP (UniProtKB | ChEBI)
Binding site275ATP (UniProtKB | ChEBI)
Active site332
Binding site588Mn2+ (UniProtKB | ChEBI)
Binding site660substrate
Binding site757Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site787Mn2+ (UniProtKB | ChEBI)
Binding site789Mn2+ (UniProtKB | ChEBI)
Binding site922substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • ORF names
      EDB92DRAFT_1983897

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • QP
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Russulales > Russulaceae > Lactarius

Accessions

  • Primary accession
    A0AAD4LQI7

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue757N6-carboxylysine
Modified residue1158N6-biotinyllysine

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-490Biotin carboxylation
Domain160-357ATP-grasp
Domain579-848Pyruvate carboxyltransferase
Domain1114-1192Lipoyl-binding

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,193
  • Mass (Da)
    130,365
  • Last updated
    2024-05-29 v1
  • Checksum
    FCB2A784BAD37472
MSTLHPPRLAPIFAATPSVPGTPVHSIQTMRRKSAGHGGPLTKILVANRGEIAVRVFRTAHELAMHTVAIYSYEDRMSAHRQKADEAYRVGAGLTPVAAYLAQDDIIRIALEHGVDMIHPGYGFLSENAEFARKVEQAGIAFVGPSPEVIDGLGDKTKARSLAIKVGVPVVPGTPGAVDKWSDADSFIKEYGFPVIIKAAMGGGGRGMRVVREESEFKNAFERAVSEAKSAFGDGTVFIERFLERPRHIEVQILGDSQGNIVHLFERDCSVQRRHQKVVEVAPATHLPEEVRQAIWADAIKLAKSVNYRNAGTAEFLVDQQGRHYFIEINPRIQVEHTITEEITGLDIVAAQIQIAAGATLPQLGLTQDAITKRGFAIQCRVTTEDAAANFQPDTGKIEVYRSAGGNGVRLDASSGFAGAQITPHYDSLLVKVSVSGTTYEVARRKMLRALVEFRIRGVKTNIPFLFRLLTHDVFIGGKTWTTFIDDTPELFKLVQTQNRAQKLLAYLGDLAVNGSSIKGQTGEPGLKDEIVIPTFQNRDDPNGPPLDATLPCEVGWRNIIVEKGPEAFAKAVREYPGTLIMDTTWRDAHQSLLATRLRTIDIANIAKETSWALSNAYSLECWGGATFDVAMRFLYEDPWERLRAIRRLVPNIPLQALVRGANGVGYTSYPDNAIYDFSKKAVENGLDIFRVFDSLNYIENMKLGIDAAKKAGGVVEAVVCYSGDVASKTETKYTLDYYLNFVEQIVAEGIHVLGIKDMAGLLKPESAKLLVGSIRAKYPDLPIHVHSHDTAGISTASMLAAAAAGADVVDVAIDSMSGLTSQPPMGAISLALEQTGLGTGIRYADIQALNLYWTQVRMLYSCFEANVRASDSSVFDHEMPGGQYTNLMFQASQLGLGTQWTEVKKKYIEANDLCGNIIKVTPSSKVVGDFAQWMTQNSLSKADVLERADQLDFPSSVVEFFQGYLGQPVGGFPEPLRSKIIRNKPRIDGRPGAGLAPLDFKKIKAELRSKFGKHITDADVTSSVMYPKVFEEYQGFLQKYGDLSVIPTRYFLGRPDVGEEMHISIEKGKTLIIRLMAVGPVVEGRAQRDVWFEVNGEVRAVAVEDKNSAVETVSREKATSDPGSVGAPMSGVVVEVRVKEGQEIKKGDPLCILSAMKMESAVTAPVSGHIKRVVVHEGDSINQGDLTVEIVH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAKELL010000002
EMBL· GenBank· DDBJ
KAH9000254.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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