A0AAD4LMB7 · A0AAD4LMB7_9AGAM
- ProteinSerine hydroxymethyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Interconversion of serine and glycine.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cobalt ion binding | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | serine binding | |
Molecular Function | zinc ion binding | |
Biological Process | folic acid metabolic process | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | L-serine catabolic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Russulales > Russulaceae > Lactarius
Accessions
- Primary accessionA0AAD4LMB7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 247 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-405 | Serine hydroxymethyltransferase-like | ||||
Sequence: LSEVDPVVQNIIDKETWRQYSGLELIASENLTSRATMEANGSILTNKYSEGLPNARYYGGNEWIDELEVLCRDRALKAFHLDPAIWGVNVQPYSGSTANFAALTALLQPQDRLMGLGLPDGGHLTHGYYTAKKKMTASSIYFQSFPYGLDPSTQLIDYSTLASQARIFKPRLIICGASAYPRDWDYEALRKVADEHGASLMADIAHTSGLVAAQELADPFKYCDVVTTTTHKTLRGPRAGLIFFRKDGEAHKDLEKRVNDAVFPACQGGPHNNTIAGIATTLLQATQPSWKVYAQQVIKNAQALADELVKHGYKLQTGGTDNHLVLWDLRPLKLTGSKVEKIGDLLGITINKNAVSGDASAQVPGGIRIGTAALTSRDMREEDLRTVAGF |
Sequence similarities
Belongs to the SHMT family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)52,343
- Last updated2024-05-29 v1
- Checksum97585E6A93C829C1
Keywords
- Technical term