A0AAD3T575 · A0AAD3T575_NEPGR

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site165-170FMN (UniProtKB | ChEBI)
Binding site220-223FMN (UniProtKB | ChEBI)
Binding site258-267FMN (UniProtKB | ChEBI)
Binding site293FMN (UniProtKB | ChEBI)
Binding site384NADP+ (UniProtKB | ChEBI)
Binding site544-547FAD (UniProtKB | ChEBI)
Binding site562-564FAD (UniProtKB | ChEBI)
Binding site578-581FAD (UniProtKB | ChEBI)
Binding site625NADP+ (UniProtKB | ChEBI)
Binding site686-687NADP+ (UniProtKB | ChEBI)
Binding site692-696NADP+ (UniProtKB | ChEBI)
Binding site728NADP+ (UniProtKB | ChEBI)
Binding site766FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • ORF names
      Nepgr_025103

Organism names

  • Taxonomic identifier
  • Strain
    • SING2019-196
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Nepenthaceae > Nepenthes

Accessions

  • Primary accession
    A0AAD3T575

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane104-124Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain159-309Flavodoxin-like
Domain364-611FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    766
  • Mass (Da)
    85,227
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    3F099F1691B0DBAD5F01BE7EF9D8056B
MCKNTIEAARLALEVEHELVQKTLLCKTEERGREGERERVVFPSNFLSLFTLCNCFQSGEAMESSSAKVSPIDLVTAILKGNFDQLNASFEESPAAIIIKSREVFMVLTTSIAVLIGCVFLVIWRRSNGQRSSRKAVELPKPLIVKEPKVEVDDGKKKVTIFFGTQTGTAEGFAKALAEEAKARYDSATFKVVDLDDYALDDDEYEEKLKKETLAFFFLATYGDGEPTDNAARFFKWFTEGNEKGEWLQDLQYGVFGLGNRQYEHFNKVAKVVDEILAQQGGKRLVPVGLGDDDKCIEDDFTAWKELVWPELDLLLLDEDSRTVSTPYTAAILEYRVVFHDPDDALIQDKSWANANGHAVHDAQHPCRANVAVRRELHTPASDRSCIHLEFDISGTGLKYETGDHVGVYCENLTQTVEEAERLLGLSPDTYFSIHTDNEDGTPISGGSLPLPFPPCTLRTALTQYADLLNSPKKSALVALAAHASDPGEADRLRFLASPAGKDEYSQWVVASQRSLLEVMAEFPSAKPPLGVFFAAVAPRLQPRYYSISSSPRLAPTRIHVTCALVYEKTPTGRIHKGVCSTWMKNAVPLDETHDSSWAPIYVRQSNFKLPADTSVPIIMIGPGTGLAPFRGFLQERFALKEAGVGLGPSILFFGCRSCKTDYIYDEELKNFVETGVISELVVAFSRDGPTKIYVQHRMMEKASDIWNMISQGGYVYVCGDAKGMAKDVHRTLHTIMQEQGSMDSSKAESMVKNLQMTGRYLRDVW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BSYO01000026
EMBL· GenBank· DDBJ
GMH23260.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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