A0AAD3T575 · A0AAD3T575_NEPGR
- ProteinNADPH--cytochrome P450 reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids766 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Catalytic activity
- 2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP+ + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD per monomer.
Note: Binds 1 FMN per monomer.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 165-170 | FMN (UniProtKB | ChEBI) | |||
Binding site | 220-223 | FMN (UniProtKB | ChEBI) | |||
Binding site | 258-267 | FMN (UniProtKB | ChEBI) | |||
Binding site | 293 | FMN (UniProtKB | ChEBI) | |||
Binding site | 384 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 544-547 | FAD (UniProtKB | ChEBI) | |||
Binding site | 562-564 | FAD (UniProtKB | ChEBI) | |||
Binding site | 578-581 | FAD (UniProtKB | ChEBI) | |||
Binding site | 625 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 686-687 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 692-696 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 728 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 766 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | NADP binding | |
Molecular Function | NADPH-hemoprotein reductase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADPH--cytochrome P450 reductase
- EC number
- Short namesCPR ; P450R
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Nepenthaceae > Nepenthes
Accessions
- Primary accessionA0AAD3T575
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 104-124 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 159-309 | Flavodoxin-like | |||
Domain | 364-611 | FAD-binding FR-type | |||
Sequence similarities
Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length766
- Mass (Da)85,227
- Last updated2024-05-29 v1
- MD5 Checksum3F099F1691B0DBAD5F01BE7EF9D8056B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BSYO01000026 EMBL· GenBank· DDBJ | GMH23260.1 EMBL· GenBank· DDBJ | Genomic DNA |