A0AAD3RVP0 · A0AAD3RVP0_NEPGR

Function

function

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site451[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site456[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site462[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site482[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site486[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site489[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site697[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentmitochondrion
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionlipoate synthase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoyl synthase, chloroplastic
  • EC number
  • Alternative names
    • Lipoate synthase
      (LS
      ; Lip-syn
      )
    • Lipoate synthase, plastidial
      (LIP1p
      )
    • Lipoic acid synthase

Gene names

    • Name
      LIP1P
    • ORF names
      Nepgr_000776

Organism names

  • Taxonomic identifier
  • Strain
    • SING2019-196
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Nepenthaceae > Nepenthes

Accessions

  • Primary accession
    A0AAD3RVP0

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-37Disordered
Compositional bias8-28Polar residues
Region57-87Disordered
Compositional bias61-80Basic and acidic residues
Domain465-686Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. Lipoyl synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    720
  • Mass (Da)
    79,850
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    7C4472A3EDBC21AB0808B6844BC9DE2E
MSFAAQAHGSQLLPSKTVPSSIRLNSKSAPPLTSPLTLPLLKCRPFTLKAKANDRISVTESDGKNGREGSPKEIYKKEKSEEEEVEEDMPWFQEKALDLVEFTGSVTQAIPGPRVGQSSLPWILALPLAYAGITFVIALVRTVRKFSSPKEKRRKLVNKNAMLCKSIDDILQKGRDKMQHSELKGLMQKTGFSMEEIMRKYIRYALNEKPFNPDMVADLIQLRKASILEDSQVAEILNEISGRIVRDKGPVVMDASGYSEKGFKRKLAVQALFQKVLYLSELPEFCSRDTSLIIKEIFGVTDEDADKLRIDTLSEAGDVDSLEKMVDGSDSEHIEISGPSISISFRSPHENIRRHKNRCLLSRIRSEFVDSSSKSSIIPTKTPPVSTIGEKLLESEGKAKGPYPGGMGVGPYRGRDPNLKKPEWLRQKAPQGDRFQDVKDSLSGLNLHTVCEEAQCPNIGECWNGGGDGIATATIMLLGDTCTRGCRFCAVKTSRNPAPPDPMEPENTAKAIASWGVDYIVLTSVDRDDLLDGGSGHFAETVKALKKLKNDIMVECLTSDFRGDLEAVETLVHSGLDVFAHNIETVKRLQRIVRDPRAGYEQSLSVLKHAKISKQGMFTKSSIMLGLGETDNELKEAMADLRSIDVDILTLGQYLQPTPLHLTVKEYVTPEKFAFWKEYGESIGFHYVASGPLVRSSYRAGELFVKTMVKERAMNTSKLS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias8-28Polar residues
Compositional bias61-80Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BSYO01000001
EMBL· GenBank· DDBJ
GMG98936.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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