A0AAD2QFD3 · A0AAD2QFD3_NEIME

  • Protein
    Aconitate hydratase B
  • Gene
    acnB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site191substrate
Binding site244-246substrate
Binding site415-417substrate
Binding site499substrate
Binding site711[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site769[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site772[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site791substrate
Binding site796substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function2-methylisocitrate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionaconitate hydratase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Biological Processpropionate catabolic process, 2-methylcitrate cycle
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aconitate hydratase B
  • EC number
  • Alternative names
    • 2-methylisocitrate dehydratase

Gene names

    • Name
      acnB
    • ORF names
      DE8555_1507
      , ERS514851_01600

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • DE8555
    • 2842STDY5881531
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0AAD2QFD3

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-156Aconitase B HEAT-like
Domain168-380Aconitase B swivel
Domain472-698Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain699-814Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    861
  • Mass (Da)
    92,787
  • Last updated
    2024-05-29 v1
  • Checksum
    7654F8C2B013A845
MLEAYRKAAAERAALGIPALPLNAQQTADLVELLKSPPAGEGEFLVELLAHRVPPGVDDAAKVKASFLAAVAEGSASSPLISPEYATELLGTMLGGYNIHTLIELLDDDKLAPIAAKGLKHTLLMFDSFHDVQEKAEKGNKYAQEVLQSWADAEWFTSRAKVPEKITVTVFKVDGETNTDDLSPAPDAWSRPDIPLHALAMLKNPRDGITPDKPGEVGPIKLLEELKAKGHPVAYVGDVVGTGSSRKSATNSVIWHTGEDIPFVPNKRFGGVCLGGKIAPIFFNTQEDSGALPIEVDVSALKMGDVVDILPYEGKIVKNGETVAEFELKSQVLLDEVQAGGRINLIIGRGLTAKAREALKLPASTAFRLPQAPAESKAGFTLAQKMVGRACGLPEGQGVRPGTYCEPRMTTVGSQDTTGPMTRDELKDLACLGFSADMVMQSFCHTAAYPKPVDVKTHKELPAFISTRGGVSLRPGDGVIHSWLNRLLLPDTVGTGGDSHTRFPIGISFPAGSGLVAFAAATGVMPLDMPESVLVRFSGKLQPGVTLRDLVNAIPLYAIKQGLLTVAKAGKKNIFSGRILEIEGLPDLKVEQAFELTDASAERSAAGCTVKLNKEPIIEYMKSNVVLMKNMIADGYQDPRTLERRIKAMEKWLANPELLEADKDAEYAAVIEINMDDIKEPIIACPNDPDDVCFMSERSGTKIDEVFIGSCMTNIGHFRAASKLLEGKADTPVRLWIAPPTKMDAKQLSDEGHYGVLGRAGARMEMPGCSLCMGNQAQVREGATVMSTSTRNFPNRLGKNTFVYLGSAELAAICSKLGKIPTVEEYQANIGIINEQGDKIYRYMNFNEIDSYNEVAETVNV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012393
EMBL· GenBank· DDBJ
ANW92051.1
EMBL· GenBank· DDBJ
Genomic DNA
FFEF01000021
EMBL· GenBank· DDBJ
CWU22169.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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