A0AAD2QFD3 · A0AAD2QFD3_NEIME
- ProteinAconitate hydratase B
- GeneacnB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids861 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 191 | substrate | |||
Binding site | 244-246 | substrate | |||
Binding site | 415-417 | substrate | |||
Binding site | 499 | substrate | |||
Binding site | 711 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 769 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 772 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 791 | substrate | |||
Binding site | 796 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 2-methylisocitrate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | aconitate hydratase activity | |
Molecular Function | metal ion binding | |
Molecular Function | RNA binding | |
Biological Process | propionate catabolic process, 2-methylcitrate cycle | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAconitate hydratase B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionA0AAD2QFD3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-156 | Aconitase B HEAT-like | |||
Domain | 168-380 | Aconitase B swivel | |||
Domain | 472-698 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | |||
Domain | 699-814 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | |||
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length861
- Mass (Da)92,787
- Last updated2024-05-29 v1
- Checksum7654F8C2B013A845
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP012393 EMBL· GenBank· DDBJ | ANW92051.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FFEF01000021 EMBL· GenBank· DDBJ | CWU22169.1 EMBL· GenBank· DDBJ | Genomic DNA |