A0AAD1NN54 · A0AAD1NN54_9GAMM

  • Protein
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • Gene
    ispF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site10a divalent metal cation (UniProtKB | ChEBI)
Binding site10-124-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site12a divalent metal cation (UniProtKB | ChEBI)
Site36Transition state stabilizer
Binding site36-374-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site44a divalent metal cation (UniProtKB | ChEBI)
Binding site58-604-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site63-674-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site102-1084-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site134-1374-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Site135Transition state stabilizer
Binding site1414-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)
Binding site1444-CDP-2-C-methyl-D-erythritol 2-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Molecular Functionmetal ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • EC number
  • Short names
    MECDP-synthase
    ; MECPP-synthase
    ; MECPS

Gene names

    • Name
      ispF
    • ORF names
      TUM17379_28760

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TUM17379
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella

Accessions

  • Primary accession
    A0AAD1NN54

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-1562-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Sequence similarities

Belongs to the IspF family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    17,079
  • Last updated
    2024-05-29 v1
  • Checksum
    7F465333E909328D
MNIRIGHGFDVHKFGGEPPLVLGGVKVPYHTGLLAHSDGDVVLHAISDAILGAMALGDIGKHFPDTDAEFKGADSRVLLRHCYRLALDKGFRLGNLDVTIIAQAPKMAPHIEAIRQMLAEDLHTDLDSINVKATTTEKLGFTGRSEGIAVEAVVLMFGM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP024613
EMBL· GenBank· DDBJ
BCV45858.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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