A0AAD1HTC3 · A0AAD1HTC3_9MYCO

  • Protein
    Amidophosphoribosyltransferase
  • Gene
    purF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site199[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site246Mg2+ (UniProtKB | ChEBI)
Binding site308Mg2+ (UniProtKB | ChEBI)
Binding site309Mg2+ (UniProtKB | ChEBI)
Binding site345[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site401[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site404[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      MTER_05180

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 12143
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacter

Accessions

  • Primary accession
    A0AAD1HTC3

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-184Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    446
  • Mass (Da)
    47,929
  • Last updated
    2024-05-29 v1
  • Checksum
    4B1F46F45D54FA97
MFKDLGLVSQVFEEQTLAAMSGHVAIGHCRYSTTGDTTWENAQPVFRNTAAGTGVALGHNGNLVNTTELAGRARRLGLIDTRRPGVATTDSDILGALLAHGAADTTLEQSALELLPTARGAFCLTFMDENTLYAARDPWGVRPLSLGRLDRGWVVASETAALDIVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGCVFEYVYLARPDSTIAGRSVHATRVEIGRRLARAHPVDADLVIGVPESGIPAAVGYAQESGIDYGQGLTKNAYVGRTFIQPSQTIRQLGIRLKLNPLREIIRGKRLIVVDDSIVRGNTQRALVRMLREAGAVEVHVRIASPPVKWPCFYGIDFASPAELIANVVEDEDEMLEAVRRTIGADSLGYVGLEEMIAATEQPRSRLCSACFDGNYPIELPSDSALGKNVVEQMLATTALQAESGNDPALIQP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022564
EMBL· GenBank· DDBJ
BBX21107.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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