A0AAD1HSU6 · A0AAD1HSU6_9MYCO

  • Protein
    Acetyl-coenzyme A synthetase
  • Gene
    acsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site194-197CoA (UniProtKB | ChEBI)
Binding site313CoA (UniProtKB | ChEBI)
Binding site389-391ATP (UniProtKB | ChEBI)
Binding site413-418ATP (UniProtKB | ChEBI)
Binding site510ATP (UniProtKB | ChEBI)
Binding site525ATP (UniProtKB | ChEBI)
Binding site533CoA (UniProtKB | ChEBI)
Binding site536ATP (UniProtKB | ChEBI)
Binding site547Mg2+ (UniProtKB | ChEBI)
Binding site549Mg2+ (UniProtKB | ChEBI)
Binding site552Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acsA
    • ORF names
      MTER_02330

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 12143
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacter

Accessions

  • Primary accession
    A0AAD1HSU6

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue620N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-83Acetyl-coenzyme A synthetase N-terminal
Domain87-486AMP-dependent synthetase/ligase
Domain541-620AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    654
  • Mass (Da)
    71,270
  • Last updated
    2024-05-29 v1
  • Checksum
    C26B9761679FF885
MSRNPDTAPTDSPSLYPPSPEFAARANTGAEAYRAAEHDRLAFWAEQANRLHWDTPFTEVLDYSAAPFARWFADGRLNVAYNCVDRHVAAGHGDRVAIHWEGEPVGDARTITYAELLTEVSRAANALTGLGLVAGDRVAIYLPMIPEAIVAMLACARLGVLHTVVFAGFSAHALRSRIDDAQAKVVITSDGQYRRGQAAALKPAVDEAVTGAESVQHVLVVRRTGGEVAWSPGRDLWWHDVVDSASAQHTPEAFEAEQPLFLLYTSGTTGKPKGIVHTSGGYLTQAAYTHYCVFDLRADSDVFWCTADIGWVTGHTYAVYGPLANGATEVIYEGTPDYPDQHRHFQIIEKYGVTIYYTAPTLIRTFKKWGREIPDAHNLSSLRLLGSVGEPINPEAWRWYRRVIGADAVPVVDTWWQTETGATMICPLPGVAAAKPGAAMRPLPGISARIVDDHGDLVSPNDAAGEPVSGYLVIDQPWPSMARGIWGDEQRFIDTYWSRFAEQGWYFAGDGARYDADGDIWVLGRIDDVMNVSGHRISTAEVESALVGHAAVAEAAVVGALDEQTGQRICAFVVLASSHTEVGGAIVDELRERVTVEISPIARPRNVHLVPELPKTRSGKIMRRLLRDIADGRELGDTSTLVDPSVFDAIRAAD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022564
EMBL· GenBank· DDBJ
BBX20822.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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