A0AAD1FIE7 · A0AAD1FIE7_PSEFK

  • Protein
    Uracil phosphoribosyltransferase
  • Gene
    upp
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site785-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site193uracil (UniProtKB | ChEBI)
Binding site198-200uracil (UniProtKB | ChEBI)
Binding site1995-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      KF707C_47800

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 10086 / NBRC 110670 / KF707
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas > Pseudomonas oleovorans/pseudoalcaligenes group

Accessions

  • Primary accession
    A0AAD1FIE7

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    22,982
  • Last updated
    2024-05-29 v1
  • Checksum
    6E7B33C8A474B283
MPIREIRHPLIRHKIGLMRRADISTKNFRELAQEVGALLTYEATNDLPLESYEIQGWAGSVQVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLEAHTYLEKLAPEIDERLALIIDPMLATGGSMVATIDLLKRAGCKEIRAMVLVAAPEGIKAVNDAHPDVMIFTASIDQKLNEHGYIIPGLGDAGDKIFGTKQKEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP014862
EMBL· GenBank· DDBJ
BAU76468.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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