A0AAD1ELH3 · A0AAD1ELH3_9MICO

  • Protein
    ATP phosphoribosyltransferase
  • Gene
    hisG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Feedback inhibited by histidine.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP phosphoribosyltransferase
  • EC number
  • Short names
    ATP-PRT
    ; ATP-PRTase

Gene names

    • Name
      hisG
    • ORF names
      C7V51_03815

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCCPB 2253
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Rathayibacter

Accessions

  • Primary accession
    A0AAD1ELH3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain57-207ATP phosphoribosyltransferase catalytic
Domain212-283Histidine biosynthesis HisG C-terminal

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    30,748
  • Last updated
    2024-05-29 v1
  • Checksum
    08AD1E49D53018A5
MTTTLASALLRVAVPNKGSLSETAGQMLAEAGYSGRRDPKELHVVDERNGVEFFYLRPRDIATYVGSGALDVGVTGRDLLIDSGSEAREIASLGFANSTFRFAGPAGRYTELTQIHGLRVATSYPGLVGRFLREHGVEVTLIRLDGAVESAIQLGVADVIADVVETGTTLRKAGLEIFGPVILDSTAVLVSAAGEPEGIPVLLRRLQGVLVARQYVLLDYDCPVALLERATALAPGFESPTVSPLHDPEWVAVRVMVPRTDMNQVMDRLYDLGARAILVTSIHAARL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP028130
EMBL· GenBank· DDBJ
AZZ55107.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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