A0AAD0W8W1 · A0AAD0W8W1_9NEIS

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site46-50GTP (UniProtKB | ChEBI)
Binding site51Zn2+ (UniProtKB | ChEBI); catalytic
Binding site62Zn2+ (UniProtKB | ChEBI); catalytic
Binding site64Zn2+ (UniProtKB | ChEBI); catalytic
Binding site67GTP (UniProtKB | ChEBI)
Binding site89-91GTP (UniProtKB | ChEBI)
Binding site111GTP (UniProtKB | ChEBI)
Active site123Proton acceptor
Active site125Nucleophile
Binding site146GTP (UniProtKB | ChEBI)
Binding site151GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      D1345_08125

Organism names

  • Taxonomic identifier
  • Strain
    • JP2-74
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chromobacteriaceae > Chromobacterium

Accessions

  • Primary accession
    A0AAD0W8W1

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-167GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    21,423
  • Last updated
    2024-05-29 v1
  • Checksum
    676B51594881A824
MEYVASCKLPTPWGEFTMHGFEEVGGREHVALTLGTIDDGEPVLSRLHSECLTGDALFSLRCDCGFQLEAALSAIAAEGRGALLYLRQEGRGIGLINKIRAYQLQDGGADTVEANERLGFPADMRDFRIARHMLEQLGVSRVRVMTNNPRKIETLRTAGIDVVERVPLEVGRNPHNDRYLDTKASKLGHMLFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP031968
EMBL· GenBank· DDBJ
AXT46148.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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