A0AAD0N0Z2 · A0AAD0N0Z2_PSESX

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site194-201ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site494Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      DA456_24945

Organism names

  • Taxonomic identifier
  • Strain
    • LMG5095
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas > Pseudomonas syringae

Accessions

  • Primary accession
    A0AAD0N0Z2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane98-120Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain186-325AAA+ ATPase
Region592-634Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    634
  • Mass (Da)
    68,907
  • Last updated
    2024-05-29 v1
  • Checksum
    5F086179266FAB03
MAKNLILWLIIAAVLVTVMNNFSSPNEPQNLNYSEFIQQVKDGKVEKVSVDGYVITGKRSDGDTFKTIRPNIPDNGLIGDLVSNNVVIEGKQPEQQSIWTQLLVASFPILVIIAVFMFFMRQMQGGAGGKGGPMSFGKSKARLLSEDQVKTTLADVAGCDEAKEEVGELVEFLRDPGKFQRLGGRIPRGVLMVGPPGTGKTLIAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKHAPCIIFIDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFEMNDGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDIRGREQILKVHMRKVPMGEDVNPGVIARGTPGFSGADLANLVNEASLFAARSGKRVVEMKEFELAKDKIMMGAERKSMVMSDKEKRNTAYHEAGHAIVGRLVPEHDPVYKVSIIPRGRALGVTMFLPEEDRYSLSKRALISQICSLYGGRIAEEMTLGFDGVTTGASNDIMRASQIARNMVTKWGLSEKLGPLMYSEDEDAGYLGRGGSQNSSVSGDTAKLIDSEVRSIIDHCYGTAKQLLTDNRDKLEAMADALMKYETIDADQIDDIMTGRTPREPRDWGGGSGTNGTPITPDPRPETPIGGPAAEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP028490
EMBL· GenBank· DDBJ
AVX26377.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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