A0AAD0EXE4 · A0AAD0EXE4_MOROS

  • Protein
    Adenylate kinase
  • Gene
    adk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.

Features

Showing features for binding site.

121820406080100120140160180200
TypeIDPosition(s)Description
Binding site11-16ATP (UniProtKB | ChEBI)
Binding site32AMP (UniProtKB | ChEBI)
Binding site37AMP (UniProtKB | ChEBI)
Binding site58-60AMP (UniProtKB | ChEBI)
Binding site86-89AMP (UniProtKB | ChEBI)
Binding site93AMP (UniProtKB | ChEBI)
Binding site124ATP (UniProtKB | ChEBI)
Binding site133-134ATP (UniProtKB | ChEBI)
Binding site157AMP (UniProtKB | ChEBI)
Binding site168AMP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular Functionnucleoside diphosphate kinase activity
Biological Processnucleoside diphosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • ATP-AMP transphosphorylase
    • ATP:AMP phosphotransferase
    • Adenylate monophosphate kinase

Gene names

    • Name
      adk
    • ORF names
      YHS_06430

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • YHS
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Moraxella

Accessions

  • Primary accession
    A0AAD0EXE4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region31-60NMP
Region123-160LID
Domain124-159Adenylate kinase active site lid

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    23,649
  • Last updated
    2024-05-29 v1
  • Checksum
    BF986B87AEB0283E
MKRIILLGPPGAGKGTQAQIITKEFNIPQISTGDMLRAAIKEGTELGKQAKSIMDAGGLVSDDLIINLVKARIAQPDCAKGCIFDGFPRTIPQAQALADAGVHIDNVVEIAVPDEDIVSRLSGRRSHPASGRVYHVIYNPPKVEGKDDETGEDLVQRDDDKEDTIRDRLATYHNQTEALVGFYQDLAKSGQNAPRYAKFDGTQAIDKVSEQVLAELKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP024176
EMBL· GenBank· DDBJ
ATQ83492.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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