A0AAD0EWM0 · A0AAD0EWM0_MOROS
- ProteinHistidine biosynthesis bifunctional protein HisIE
- GenehisI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids285 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | phosphoribosyl-AMP cyclohydrolase activity | |
Molecular Function | phosphoribosyl-ATP diphosphatase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHistidine biosynthesis bifunctional protein HisIE
Including 2 domains:
- Recommended namePhosphoribosyl-AMP cyclohydrolase
- EC number
- Short namesPRA-CH
- Recommended namePhosphoribosyl-ATP pyrophosphatase
- EC number
- Short namesPRA-PH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Moraxella
Accessions
- Primary accessionA0AAD0EWM0
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-168 | Phosphoribosyl-AMP cyclohydrolase | |||
Domain | 29-103 | Phosphoribosyl-AMP cyclohydrolase | |||
Region | 126-164 | Disordered | |||
Compositional bias | 138-164 | Polar residues | |||
Region | 169-285 | Phosphoribosyl-ATP pyrophosphohydrolase | |||
Sequence similarities
In the C-terminal section; belongs to the PRA-PH family.
In the N-terminal section; belongs to the PRA-CH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length285
- Mass (Da)31,695
- Last updated2024-05-29 v1
- MD5 ChecksumC5F3AB60F893F6F163ABAE60C42C18EC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 138-164 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP024176 EMBL· GenBank· DDBJ | ATQ82550.2 EMBL· GenBank· DDBJ | Genomic DNA |