A0AAD0APV2 · A0AAD0APV2_9FUSO
- ProteinPyridoxal 5'-phosphate synthase subunit PdxS
- GenepdxS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids280 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Catalytic activity
- aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H+ + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
Pathway
Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 69 | Schiff-base intermediate with D-ribose 5-phosphate | ||||
Sequence: K | ||||||
Binding site | 141 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 153 | D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 202 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 223-224 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: GS |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity | |
Biological Process | pyridoxal phosphate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyridoxal 5'-phosphate synthase subunit PdxS
- EC number
- Short namesPLP synthase subunit PdxS
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Fusobacteriota > Fusobacteriia > Fusobacteriales > Fusobacteriaceae > Fusobacterium
Accessions
- Primary accessionA0AAD0APV2
Proteomes
Interaction
Subunit
In the presence of PdxT, forms a dodecamer of heterodimers.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-200 | PdxS/SNZ N-terminal | ||||
Sequence: RFNGGVIMDVTSKEQAIIAEEAGAVAVMALERIPADIRAAGGVSRMSDPKLIKEIMSAVKIPVMAKVRIGHFVEAEILQAIGIDFIDESEVLSPADSVHHVNKRDFTTPFVCGARNLGEALRRICEGAQMIRTKGEAGTGDVVQAVSHMRQIMKEINLVKALRDDELYVMAKDLQVPYDLVKYVHDNGRLPVPNFSA |
Sequence similarities
Belongs to the PdxS/SNZ family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length280
- Mass (Da)30,308
- Last updated2024-05-29 v1
- ChecksumDD9729408395F7A3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP024700 EMBL· GenBank· DDBJ | ATV62672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP024702 EMBL· GenBank· DDBJ | ATV65258.1 EMBL· GenBank· DDBJ | Genomic DNA |