A0AAC9P7P1 · A0AAC9P7P1_9PROT

Function

function

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site216substrate
Binding site245substrate
Binding site274substrate
Binding site310substrate
Binding site330-332substrate
Binding site371-374substrate
Binding site410substrate
Binding site414Zn2+ (UniProtKB | ChEBI)
Binding site437substrate
Binding site478Zn2+ (UniProtKB | ChEBI)
Binding site558[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site561[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site566[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-carbon lyase activity
Molecular Functionzinc ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomethylpyrimidine synthase
  • EC number
  • Alternative names
    • Hydroxymethylpyrimidine phosphate synthase
      (HMP-P synthase
      ; HMP-phosphate synthase
      ; HMPP synthase
      )
    • Thiamine biosynthesis protein ThiC

Gene names

    • Name
      thiC
    • ORF names
      GbCGDNIH9_0108

Organism names

  • Taxonomic identifier
  • Strain
    • NIH9.1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter

Accessions

  • Primary accession
    A0AAC9P7P1

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-83ThiC-associated

Sequence similarities

Belongs to the ThiC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    66,923
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    FBD2EC0DEA60EEC11ED95C9C8C891498
MTVQTKPTTVTLGPITGSRKIYVPVEGRDDMAIPFREIALDPSAAEDPVRVYDTSGPYTDPSSHIDLEQGLPPLRAPWLARRGYASVTPREVTAADNGYAPADRLVTPCPAPHTVFEGKPGQLVTQLEFARAGIITEEMIYVAHRENMGRARMLEGAEARRADGEDFGASIPAFITPEFVRAEVAAGRAIIPANINHPEIEPMAIGRNFLVKINANIGNSAVTSSAAEEVEKMVWATRWGADTVMDLSTGRNIHNIRGWIMRNSPVPIGTVPIYQALEKVGGEAEKLSWEVFRDTLIEQAEQGVDYFTIHAGVRLAHVPLTASRVTGIVSRGGSIMARWCLSHHRESFLYERFGEICEIMRKYDVSFSLGDGLRPGSIADANDAAQFAELETLGELTKIAWDHGCQVMIEGPGHVPMHKIKANMDKQLAVCGEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWFGTAMLCYVTPKEHLGLPDRNDVKTGVITYRIAAHAADLAKGHPSARLRDDAVSRARFSFRWQDQFNLSLDPDTAQAFHDETMPKEAHKVAHFCSMCGPKFCSMKITQDLREEAARMAGMESKSAEFRDMGATLYVPEHAPAKEDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018191
EMBL· GenBank· DDBJ
APH53330.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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