A0AAC9P7C4 · A0AAC9P7C4_9PROT

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site76-79substrate
Binding site98substrate
Binding site99Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionmethyltransferase activity
Molecular Functionribonuclease inhibitor activity
Biological Processmethylation
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      GbCGDNIH9_0063

Organism names

  • Taxonomic identifier
  • Strain
    • NIH9.1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter

Accessions

  • Primary accession
    A0AAC9P7C4

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    163
  • Mass (Da)
    16,586
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    C7FA120CD4B1CBD375157D10CCFD7A06
MMVFATADLVDAYQDRLGSCFIQFASYGGHAGFSGPVRTIRTYEDNALIKATLSSPGQGAVLVIDGGGSLRSALVGDVIAGLAVQNGWAGIIVWGVVRDSVALKTLPLGIKALGTNPWKSGKAGSGVLDAPVSFGGVTFATGDWVYADEDGLLVSAGGALPQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018191
EMBL· GenBank· DDBJ
APH53286.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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