A0AAC9KFB8 · A0AAC9KFB8_9PROT

  • Protein
    Dihydrofolate synthase/folylpolyglutamate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processfolic acid biosynthetic process
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      GbCGDNIH9_2012

Organism names

  • Taxonomic identifier
  • Strain
    • NIH9.1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter

Accessions

  • Primary accession
    A0AAC9KFB8

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain48-263Mur ligase central
Domain303-415Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    45,355
  • Last updated
    2024-05-29 v1
  • Checksum
    570D309EEB2AC911
MSKGRTEAVIERLHGLHPKMIDLSLGRLEALLEKLGHPERSLPPVVHVAGTNGKGSTCAFLRALAEAAGQRVHVYISPHLVQFNERIRLAGELVSEPVLVEALEEVERVNAGAPITVFEVITAVALLLFSRIPADLCVVEVGLGGRFDATNVVTPLVSAIASISIDHREYLGDDIRGIAAEKAGILKSGAPGVTGLQLPDVLEVLDREAAKQGVRLLARDRDWHIARHGNGLRYSDADGVVELPLPALPGEHQLDNAGIAVAAMRAAAKTATPLSWLAEGLARAEWPARMQRLTGLLAKNLPAGWELWLDGGHNPGAGVMLAGHLRGWKDRPAHVIVGMKQAKDAGQFLASVLPEADTVWAIAEPGQYLALPVAAIVSASGGKAIPGPTVREAMAAILKQAEAGGVPGRILICGSLYLAGEILKLDQGLA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018191
EMBL· GenBank· DDBJ
APH55328.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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