A0AAC9KEJ6 · A0AAC9KEJ6_9PROT

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

130320406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site41substrate
Binding site75substrate
Binding site93substrate
Active site102
Active site102Proton donor
Binding site103-104substrate
Binding site181substrate
Site183Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site214substrate
Site232Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site232-233substrate
Active site241Proton acceptor
Binding site242-243substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      GbCGDNIH9_1500

Organism names

  • Taxonomic identifier
  • Strain
    • NIH9.1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter

Accessions

  • Primary accession
    A0AAC9KEJ6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    303
  • Mass (Da)
    32,203
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    C7DC165F217186388EBF18DA08440EC7
MEFGQSLIGYAEAKIVLLTDAYALYKGGMLTDFIKMHGLGNDFVVFDARKGRKLALSGSQAAAIADRRTGVGCDQLIVLEPSSVADAFMRIYNPDGSESGACGNATRCIADLLHRDGIAAPSMETVAGLLRAEITGDGICIDMGQPGLGWRDVPLAREMDTLFLPLEAPGLKMPAACSMGNPHATFFVADLAALDIPATGPMLEHDPLFPERANIGHAQMLSRSHIRLRVWERGAGLTLACGTGACATLVNAVRRGLAEREAVVELDGGQLRIHWREQDGHVLMTGPAATVFHGRIALESIAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018191
EMBL· GenBank· DDBJ
APH54803.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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