A0AAC9KD40 · A0AAC9KD40_9PROT

  • Protein
    ADP-L-glycero-D-manno-heptose-6-epimerase
  • Gene
    hldD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

NADP+ (UniProtKB | Rhea| CHEBI:58349 )

Note: Binds 1 NADP+ per subunit.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-14NADP+ (UniProtKB | ChEBI)
Binding site34-35NADP+ (UniProtKB | ChEBI)
Binding site41NADP+ (UniProtKB | ChEBI)
Binding site75-79NADP+ (UniProtKB | ChEBI)
Active site145Proton acceptor
Binding site149NADP+ (UniProtKB | ChEBI)
Binding site176substrate
Binding site177NADP+ (UniProtKB | ChEBI)
Active site185Proton acceptor
Binding site185NADP+ (UniProtKB | ChEBI)
Binding site187substrate
Binding site194substrate
Binding site208-211substrate
Binding site222substrate
Binding site287substrate

GO annotations

AspectTerm
Molecular FunctionADP-glyceromanno-heptose 6-epimerase activity
Molecular FunctionNADP binding
Biological Processcarbohydrate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-L-glycero-D-manno-heptose-6-epimerase
  • EC number
  • Alternative names
    • ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      (ADP-glyceromanno-heptose 6-epimerase
      ; ADP-hep 6-epimerase
      ; AGME
      )

Gene names

    • Name
      hldD
    • ORF names
      GbCGDNIH9_1533

Organism names

  • Taxonomic identifier
  • Strain
    • NIH9.1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter

Accessions

  • Primary accession
    A0AAC9KD40

Proteomes

Interaction

Subunit

Homopentamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-250NAD-dependent epimerase/dehydratase

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    36,933
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    E50038DBBD548E2DE7FAAEE46C3A9F2C
MTALIILTGGAGFIGSNIAAELNGAGHTDIVIIDWLGTERKWHNIAKRRFADFVFPEEVNTFLDGLKGADAVVHMGANSSTTATDGDEIIRSNFRLSCRLWNWCAATGTPFIYASSAATYGDGRMGFVDDDSDAGLDALHPLNLYGWSKHAFDKWALERARRHDAPPQWVGLKFFNVYGPNEYHKKDMMSLVAKNTPLILDGQTIRLFKSHRPEFADGEQLRDFIYVKDCASVVTWLLQNRHVSGLFNLGTGKARSFRDLMLAVGQAAGKTTSIEFVDMPASIRDQYQYFTEASMHKLRAAGYTQDFYTLEEGVRDYVQTYLIPQDQYR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018191
EMBL· GenBank· DDBJ
APH54817.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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