A0AAC9KD40 · A0AAC9KD40_9PROT
- ProteinADP-L-glycero-D-manno-heptose-6-epimerase
- GenehldD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids329 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Catalytic activity
- ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
Cofactor
Note: Binds 1 NADP+ per subunit.
Pathway
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 13-14 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 34-35 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 41 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 75-79 | NADP+ (UniProtKB | ChEBI) | |||
Active site | 145 | Proton acceptor | |||
Binding site | 149 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 176 | substrate | |||
Binding site | 177 | NADP+ (UniProtKB | ChEBI) | |||
Active site | 185 | Proton acceptor | |||
Binding site | 185 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 187 | substrate | |||
Binding site | 194 | substrate | |||
Binding site | 208-211 | substrate | |||
Binding site | 222 | substrate | |||
Binding site | 287 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ADP-glyceromanno-heptose 6-epimerase activity | |
Molecular Function | NADP binding | |
Biological Process | carbohydrate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-L-glycero-D-manno-heptose-6-epimerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodospirillales > Acetobacteraceae > Granulibacter
Accessions
- Primary accessionA0AAC9KD40
Proteomes
Interaction
Subunit
Homopentamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 5-250 | NAD-dependent epimerase/dehydratase | |||
Domain
Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
Sequence similarities
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length329
- Mass (Da)36,933
- Last updated2024-05-29 v1
- MD5 ChecksumE50038DBBD548E2DE7FAAEE46C3A9F2C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP018191 EMBL· GenBank· DDBJ | APH54817.1 EMBL· GenBank· DDBJ | Genomic DNA |